Radiofrequency-responsive poly(combretastatin ionic liquid) nanogels for themo-boosting trans-arterial vascular disruption-embolization

IF 10.7 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-24 DOI:10.1016/j.nantod.2026.103130

Le Zhao, Bo Sun, Xin Yang, Mengqin Guo, Yan Liu, Chao Liu, Zhihao Su, Chuansheng Zheng, Xiangliang Yang, Yanbing Zhao

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引用次数: 0

Abstract

Trans-arterial chemoembolization (TACE), a first-line treatment for intermediate-/advanced-stage hepatocellular carcinoma (HCC), is heavily limited by tumor vascular heterogeneity and poor drug penetration. In this study, a temperature/radiofrequency (RF)-responsive poly(ionic liquid) nanogel (poly(N-isopropylacrylamide-b-1-butyl-3-vinylimidazolium combretastatin A4 phosphate), PIV·CA) was designed to achieve thermo-boosting trans-arterial vascular disruption-embolization (TAVDE) via RF-triggered release/penetration promotion of combretastatin A4 phosphate (CA4P) and temperature-sensitive sol-gel phase transition. The RF field shockingly increased the cytotoxicity of PIV·CA by approximately 22-fold, increasing the interaction of CA4P with tubulin and resulting in cell cycle arrest in the G2/M phase via increased suppression of tubulin polymerization. PIV·CA precisely synergizes vascular disruption, arterial embolization and RF ablation, suggesting a potential strategy of RF-energized TAVDE in transarterial therapy.

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射频响应多离子液体（combretastatin离子液体）纳米凝胶用于热增强经动脉血管阻断栓塞

经动脉化疗栓塞（TACE）是中晚期肝细胞癌（HCC）的一线治疗方法，但受肿瘤血管异质性和药物渗透不良的严重限制。在这项研究中，设计了一种温度/射频（RF）响应的多（离子液体）纳米凝胶（聚（n-异丙基丙烯酰胺-b-1-丁基-3-乙烯基咪唑combretastatin A4 phosphate）， PIV·CA），通过RF触发的combretastatin A4 phosphate （CA4P）的释放/渗透促进和温度敏感的溶胶-凝胶相变来实现热促进经动脉血管阻断栓塞（TAVDE）。RF场令人震惊地将PIV·CA的细胞毒性提高了约22倍，增加了CA4P与微管蛋白的相互作用，并通过增加对微管蛋白聚合的抑制导致细胞周期在G2/M期停滞。PIV·CA可以精确地协同血管破裂、动脉栓塞和射频消融，提示射频激活TAVDE在经动脉治疗中的潜在策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.