Mind - body interaction system: An unforeseen perspective of holistic health

Brain Behavior and Immunity Integrative Pub Date : 2026-07-01 Epub Date: 2026-07-21 DOI:10.1016/j.bbii.2026.100180

A. Srivastava, R. Verma

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Abstract

Psychoneuroimmunology (PNI) offers a cohesive model explaining the interrelationships among psychological phenomena and the nervous, endocrine, and immune systems. While the fundamental principles of PNI are well documented, translating these multidimensional interactions into actionable experimental frameworks remains a challenge. This paper advances the current PNI literature by proposing a refined bio-psycho-social framework rooted in systems biology. By structurally mapping physiological mechanisms, from molecular cytokines to systemic neuroendocrine responses to environmental and psychological factors, this perspective bridges theoretical PNI and personalized healthcare routine. This review article contributes towards providing better understanding of these bidirectional pathways which clarifies the necessity for a multi-targeted, individualized healthcare system that integrates pharmacological interventions, evidence-based lifestyle changes, and mind-body therapies, ultimately improving experimental efficacy and holistic health outcomes.

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身心互动系统：整体健康不可预见的视角

心理神经免疫学（PNI）提供了一个有凝聚力的模型来解释心理现象与神经、内分泌和免疫系统之间的相互关系。虽然PNI的基本原则有很好的文献记载，但将这些多维互动转化为可操作的实验框架仍然是一个挑战。本文通过提出一个基于系统生物学的精细生物-心理-社会框架来推进当前的PNI文献。通过构造生理机制，从分子细胞因子到环境和心理因素的系统神经内分泌反应，该视角将理论PNI与个性化医疗保健常规联系起来。这篇综述文章有助于更好地理解这些双向途径，阐明了建立一个多目标、个性化的医疗保健系统的必要性，该系统将药物干预、循证生活方式改变和身心治疗结合起来，最终提高实验疗效和整体健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Brain Behavior and Immunity Integrative

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