Arterial Stiffness and Cognitive Impairment in Patients With Arterial Hypertension: CAVI and haSTART Index.

IF 0.7 Q2 PERIPHERAL VASCULAR DISEASE

International Journal of Vascular Medicine Pub Date : 2026-07-28 eCollection Date: 2026-01-01 DOI:10.1155/ijvm/9456777

T A Safronova, S E Mukhanova, T S Vargina, A I Tarzimanova, A E Pokrovskaya, E R Konchenko, A G Cherepanov, V I Podzolkov

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引用次数: 0

Abstract

Introduction: Increased arterial stiffness is recognized as one of the established risk factors for cardiovascular diseases (CVDs), including the onset of cognitive impairment (CogI) and vascular dementia.

Aim: The objective of our study was to investigate the relationship between the cardio-ankle vascular index (CAVI) and the STELARI heart-ankle STiffness of ARTeries (haSTART) index in patients diagnosed with arterial hypertension (HTN) devoid of comorbidities. The secondary aim of the study was to explore the association of these indices with CI in patients with HTN.

Methods: Arterial stiffness was assessed using CAVI and the haSTART index. Cognitive status of all patients was obtained via the Montreal Cognitive Assessment (MoCA).

Results: A total cohort of 128 patients (55 men and 73 women, aged 35-79 years) was incorporated into the single-center study, comprising 96 subjects with essential HTN (Group 1) and 32 with no HTN in history (Group 2-controls). A robust correlation was observed upon examining CAVI and the haSTART index in all subjects (r = 0.977, p < 0.001). Moreover, significant correlations were identified between the MoCA results and CAVI (r = -0.502, p = 0.001) and the haSTART index (r = -0.512, p = 0.001).

Conclusion: The results of the study indicated a relationship between arterial stiffness and CI, as evidenced by the association between CAVI and MoCA results. Furthermore, we identified for the first time a correlation between the haSTART index and MoCA, thereby reflecting the association between arterial stiffness and CI.

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动脉高血压患者的动脉僵硬和认知障碍：CAVI和haSTART指数。

动脉僵硬度升高被认为是心血管疾病（cvd）的危险因素之一，包括认知障碍（CogI）和血管性痴呆的发病。目的：本研究的目的是探讨无合并症的动脉高血压（HTN）患者心踝血管指数（CAVI）和STELARI心踝动脉僵硬度（haSTART）指数之间的关系。该研究的次要目的是探讨这些指标与HTN患者CI的关系。方法：采用CAVI和haSTART指数评价动脉僵硬度。所有患者的认知状况均通过蒙特利尔认知评估（MoCA）获得。结果：128例患者（男性55例，女性73例，年龄35-79岁）被纳入单中心研究，其中96例患者患有原发性HTN（1组），32例患者无HTN（2组对照）。在检测所有受试者的CAVI和haSTART指数时观察到强相关（r = 0.977, p < 0.001）。此外，MoCA结果与CAVI （r = -0.502, p = 0.001）和haSTART指数（r = -0.512, p = 0.001）之间存在显著相关性。结论：本研究结果表明动脉硬度与CI之间存在一定的关系，CAVI和MoCA结果之间存在一定的相关性。此外，我们首次确定了haSTART指数与MoCA之间的相关性，从而反映了动脉硬度与CI之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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