The effect of platelet-rich fibrin glue on mucosal healing after septoplasty: a randomised controlled trial.

IF 1.1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2026-07-28 DOI:10.1017/S0022215126105398

Ahmed S Abdelhamid, Ahmed Ibrahim Abdallah, Ahmed Younes, Asmaa Embarak Hassan, Saad Elzayat

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Abstract

Objectives: This study aimed to assess whether intra-operative autologous platelet-rich fibrin glue accelerates nasal mucosal healing after septoplasty.

Methods: Prospective, randomised controlled trial of 100 adults undergoing septoplasty, randomised to platelet-rich fibrin glue (n = 50) or standard surgery (n = 50). Primary outcome: endoscopic healing via modified Lund-Kennedy score. Secondary outcomes: Visual Analog Scale pain, crusting, Nasal Obstruction Symptom Evaluation scores and complications.

Results: Platelet-rich fibrin glue significantly accelerated epithelialisation at one week (2.72 vs. 3.46, p = 0.028) and two weeks (1.49 vs. 2.17, p = 0.006). Pain, crusting and Nasal Obstruction Symptom Evaluation scores improved significantly in the platelet-rich fibrin glue group during early follow-up (p < 0.05). No significant differences were observed between groups at four or 12 weeks. Complication rates were low and comparable.

Conclusion: Intra-operative platelet-rich fibrin glue accelerates early mucosal healing and reduces post-operative morbidity during first two weeks after septoplasty without increasing complications. These benefits are confined to early recovery, with equivalent long-term outcomes.

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富血小板纤维蛋白胶对鼻中隔成形术后粘膜愈合的影响：一项随机对照试验。

目的：本研究旨在评估术中自体富血小板纤维蛋白胶是否加速鼻中隔成形术后鼻黏膜愈合。方法：前瞻性，随机对照试验，100名接受中隔成形术的成年人，随机分为富血小板纤维蛋白胶组（n = 50）或标准手术组（n = 50）。主要结果：内窥镜下通过修改的隆德-肯尼迪评分愈合。次要结局：视觉模拟量表疼痛、结痂、鼻塞症状评估评分和并发症。结果：富血小板纤维蛋白胶在1周（2.72 vs. 3.46, p = 0.028）和2周（1.49 vs. 2.17, p = 0.006）显著加速上皮化。富血小板纤维蛋白胶组患者早期随访时疼痛、结痂、鼻塞症状评价评分均显著改善（p < 0.05）。在第4周和第12周，两组间无显著差异。并发症发生率低且具有可比性。结论：术中富血小板纤维蛋白胶加速早期粘膜愈合，减少鼻中隔成形术后两周的术后发病率，且未增加并发症。这些好处仅限于早期恢复，具有同等的长期效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.