Feasibility of lung ultrasound-guided positive end-expiratory pressure adjustment in newborns.

IF 2.3 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2026-07-28 DOI:10.1038/s41372-026-02831-6

Anna Holst Møller, Christian Heiring, Sebastian Pornpakdee Feldskou, Katrin Klebermass-Schrehof, Mette Høj Lauridsen, Kasper Jacobsen Kyng

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引用次数: 0

Abstract

Objective: To evaluate whether an ultrasound-guided lung recruitment manoeuvre (LRM) can identify a positive end-expiratory pressure (PEEP) associated with improved aeration compared with clinically set PEEP during non-invasive respiratory support.

Study design: Feasibility study of 11 spontaneously breathing infants on continuous positive airway pressure or non-invasive ventilation. PEEP was increased stepwise by 2 cmH₂O from 4 to 10 cmH₂O. The PEEP with the lowest lung ultrasound score was recorded along with vital parameters.

Results: In 10 of 11 infants (91%; 95% confidence interval 62-99, p = 0.01), the LRM identified a PEEP with a lower lung ultrasound score than the clinically set level; five infants required a higher and five a lower PEEP. Clinical parameters were stable or improved.

Conclusion: In this pilot cohort, lung ultrasound-guided PEEP adjustment appeared feasible and was associated with favourable short-term changes in lung aeration. Larger studies are required to validate these preliminary findings and determine clinical utility.

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超声引导下新生儿肺呼气末正压调节的可行性。

目的：评价超声引导下的肺补充操作（LRM）在无创呼吸支持下是否能识别与通气改善相关的呼气末正压（PEEP），并与临床设定的PEEP进行比较。研究设计：11例自主呼吸婴儿持续气道正压通气或无创通气的可行性研究。PEEP由4 ~ 10 cmH2O逐步增加2 cmH2O。记录肺超声评分最低的PEEP及重要参数。结果：11例婴儿中有10例（91%，95%可信区间62 ~ 99，p = 0.01）， LRM识别出的PEEP肺超声评分低于临床设定水平；5个婴儿需要更高的PEEP， 5个婴儿需要更低的PEEP。临床参数稳定或改善。结论：在这个试点队列中，超声引导的肺正压调节似乎是可行的，并且与肺通气的有利短期变化有关。需要更大规模的研究来验证这些初步发现并确定临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.