Association between pulse pressure and markers of cognitive function: a systematic review and meta-analysis.

IF 5.6 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Journal of Hypertension Pub Date : 2026-10-01 Epub Date: 2026-07-24 DOI:10.1097/HJH.0000000000004401

Olivia Gaunt, Kaavya Venkatesh, Ryan McNally, Phil J Chowienczyk, Marina Cecelja

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引用次数: 0

Abstract

Our aim was to systematically review and meta-analyse evidence on the association between pulse pressure (PP) and cognitive function using PubMed, PsycInfo, Embase and Scopus (inception-July 2025) publication databases. Studies were included if they reported an association between PP and cognitive function and summarized narratively and by performing fixed-effects meta-analysis. The search identified 4171 publications with 43 studies meeting inclusion criteria. Domains assessed included global cognition, memory, language, attention, executive function, processing speed and visuospatial ability. Meta-analysis suggests a positive association between PP and global cognition, and a negative association with memory in both cross-sectional and longitudinal studies with inconsistent findings from narratively summarized studies. Processing speed, executive function and language negatively associated with PP in cross-sectional studies with limited evidence provided by longitudinal studies or narratively summarized studies. There was limited evidence of an association with attention and visuospatial ability.

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脉压与认知功能标志物之间的关系：系统回顾和荟萃分析。

我们的目的是使用PubMed、PsycInfo、Embase和Scopus（启动- 2025年7月）出版数据库系统地回顾和荟萃分析脉压（PP）与认知功能之间的关联证据。如果研究报告了PP与认知功能之间的关联，并通过叙述和固定效应荟萃分析进行总结，则纳入研究。检索确定了4171篇出版物，其中43篇研究符合纳入标准。评估的领域包括全球认知、记忆、语言、注意力、执行功能、处理速度和视觉空间能力。荟萃分析表明，横断面和纵向研究表明，PP与整体认知呈正相关，与记忆负相关，但叙述性总结研究的结果不一致。处理速度、执行功能和语言与PP呈负相关的横断面研究，纵向研究或叙述性总结研究提供的证据有限。有有限的证据表明它与注意力和视觉空间能力有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hypertension 医学-外周血管病

CiteScore

7.90

自引率

6.10%

发文量

1389

审稿时长

3 months

期刊介绍： The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.