Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-24 eCollection Date: 2026-07-01 DOI:10.1002/dad2.70429

Abi Heller-Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren

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Abstract

Introduction: We assessed whole hippocampal and subfield volumes, in association with memory ability, in a sample including cognitively unimpaired (CU) older adults and those in early syndromic stages of pathological aging, here subjective cognitive decline (SCD) and mild cognitive impairment (MCI).

Methods: Participants completed a battery of neuropsychological tests and a 3T magnetic resonance imaging brain study that included high-resolution T2-weighted images of hippocampus and its subfields: subiculum; cornu ammonis 1, 2, and 3 (CA1, CA2, CA3); and dentate gyrus (DG).

Results: Significant differences were found in the left whole hippocampus, left subiculum, CA1, and DG volumes in the MCI group compared to the CU or SCD groups. Least absolute shrinkage and selection operator regression techniques revealed that left subiculum and left CA1 volume significantly predicted memory ability above and beyond whole hippocampal and other subfield volumes.

Discussion: We found clinical differences in memory ability in older adults were associated with focal differences in specific hippocampal subfield volumes.

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认知受损的老年人相对于认知未受损的老年人的局灶性海马亚区萎缩与记忆能力有关。

我们评估了与记忆能力相关的整个海马和子野体积，样本包括认知未受损（CU）的老年人和处于病理性衰老早期综合征阶段的老年人，这里是主观认知衰退（SCD）和轻度认知障碍（MCI）。方法：参与者完成了一系列神经心理测试和3T脑磁共振成像研究，包括海马及其子场的高分辨率t2加权图像：耻骨下；玉米氨1、2、3 (CA1、CA2、CA3)；和齿状回（DG）。结果：与CU或SCD组相比，MCI组左海马全区、左托下区、CA1、DG体积均有显著差异。最小绝对收缩和选择算子回归技术显示，左侧肩带下和左侧CA1体积对记忆能力的预测显著高于整个海马和其他子野体积。讨论：我们发现老年人记忆能力的临床差异与特定海马亚区体积的局灶性差异有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.