Perioperative Outcomes Following Single-Stage Surgery for Tandem Spinal Stenosis-A Single-Center Retrospective Cohort.

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Adham M Khalafallah, Manav Daftari, Tanuj Prajapati, Sebastian Vargas-George, Anurag Aka, Christian K Ramsoomair, Malek Bashti, Seth S Tigchelaar, Timur Urakov
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Abstract

Objectives: Tandem spinal stenosis (TSS) is often underdiagnosed and traditionally managed with multi-stage surgery (MSS). Single-stage surgery (SSS) is an alternative, but prior studies largely emphasize younger, healthier patients. This study evaluated perioperative and functional outcomes after SSS for TSS in a surgically diverse cohort. Methods: A retrospective chart review included 20 patients who underwent SSS for TSS at a single academic institution. Mean age was 63.75 years, and median modified frailty index was 2. Etiologies included degenerative, traumatic, and neoplastic disease across cervical, thoracic, and lumbar regions. Outcomes included operative characteristics, complications, readmissions, and functional recovery measured by Visual Analog Scale (VAS) pain and modified Japanese Orthopaedic Association (mJOA) scores. Results: The mean number of operated levels was 5.2, mean operative time was 232.4 min, total OR time was 355.1 min, and length of stay was 6.9 days. Surgical complications occurred in 15% of patients, medical complications in 25%, and 90-day readmission in 15%, with no 30-day mortality. Mean mJOA improved from 12.86 at baseline to 16.08 at first follow-up and 16.46 at 3 months; REML mixed-effects modeling showed a significant timepoint effect (F (4, 34.55) = 9.15, p < 0.001), with significant Sidak-adjusted improvement at both timepoints. VAS pain showed no significant longitudinal effect. Conclusions: SSS for TSS appears feasible in a real-world, surgically diverse cohort including older and moderately frail patients. These findings support individualized SSS candidacy assessment.

串联椎管狭窄单期手术围手术期预后:单中心回顾性队列研究。
目的:串联式椎管狭窄(TSS)经常被误诊,传统上采用多阶段手术(MSS)治疗。单阶段手术(SSS)是另一种选择,但先前的研究主要强调年轻、健康的患者。本研究在一个手术多样化的队列中评估了SSS治疗TSS后的围手术期和功能结果。方法:回顾性分析20例在同一学术机构接受SSS治疗TSS的患者。平均年龄63.75岁,修正衰弱指数中位数为2。病因包括颈椎、胸椎和腰椎的退行性、外伤性和肿瘤性疾病。结果包括手术特征、并发症、再入院和功能恢复,测量方法为视觉模拟量表(VAS)疼痛和修改的日本骨科协会(mJOA)评分。结果:平均手术节数5.2节,平均手术时间232.4 min,总手术时间355.1 min,住院时间6.9 d。15%的患者发生手术并发症,25%的患者发生内科并发症,15%的患者在90天内再次入院,无30天死亡率。平均mJOA从基线时的12.86改善到第一次随访时的16.08和3个月时的16.46;REML混合效应模型显示了显著的时间点效应(F (4,34.55) = 9.15, p < 0.001),在两个时间点上均有显著的sidak校正改善。VAS疼痛无明显纵向效应。结论:SSS治疗TSS在现实世界中是可行的,手术多样化的队列包括老年和中度虚弱的患者。这些发现支持个体化SSS候选资格评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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