Hodgkin lymphoma of the ampulla of Vater: A rare cause of obstructive jaundice in children.

JPGN reports Pub Date : 2026-04-07 eCollection Date: 2026-08-01 DOI:10.1002/jpr3.70172
Sultana Alshammari, Homoud Alhebbi, Awad Al Qahtani, Sarah Algubaisi, Faisal Alhaffaf, Abdulrahman Al Robayan, Mohammed Almutairi, Saeed Alshieban, Mohammad Alshahrani, Tarek Khaled Alfawzan, Khalid Alkhamis, Ibrahim Al Hasan, Sami Wali
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Abstract

Hodgkin lymphoma (HL) has a wide spectrum of presentation. Most cases affect lymph nodes (nodal), while extranodal involvement is rare. Whereas the gastrointestinal tract is enriched with lymphoid tissues, the ampulla of Vater is not rich in lymphoid tissue. Involvement of the ampulla of Vater with HL has rarely been reported in adults and has never been reported in children. Its presentation mimics other causes of obstructive jaundice, and immunodeficiency increases the risk of lymphoma. There have been reports of cutaneous T-cell lymphomas and one case of HL following the use of dupilumab, a biological agent that has been used to treat atopic dermatitis. Here, we report a case of HL of the ampulla of Vater in a patient with hyper-IgE syndrome type 2 and severe atopic dermatitis.

壶腹霍奇金淋巴瘤:儿童梗阻性黄疸的罕见病因。
霍奇金淋巴瘤(HL)具有广泛的表现。大多数病例累及淋巴结(结),而结外累及罕见。虽然胃肠道富含淋巴组织,但水壶腹并不富含淋巴组织。累及壶腹的HL在成人中很少有报道,在儿童中也从未报道过。它的表现类似于梗阻性黄疸的其他原因,免疫缺陷增加了淋巴瘤的风险。有皮肤t细胞淋巴瘤的报道,在使用杜匹单抗(一种用于治疗特应性皮炎的生物制剂)后发生了一例HL。在这里,我们报告一例高ige综合征2型和严重特应性皮炎患者的壶腹HL。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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