Nicole Touriel Bornsztein, Ariela Grabarz, Ana Laura Donaire Rapozero, Roberta Facchini Jardim Criado, Paulo Ricardo Criado, Gabriela Izzo Luiz, Luisa Homem de Mello Maciel Campilongo, Denise Maria Christofolini
{"title":"Autoimmune progesterone dermatitis: diagnostic relevance and epidemiological analysis of 13 cases.","authors":"Nicole Touriel Bornsztein, Ariela Grabarz, Ana Laura Donaire Rapozero, Roberta Facchini Jardim Criado, Paulo Ricardo Criado, Gabriela Izzo Luiz, Luisa Homem de Mello Maciel Campilongo, Denise Maria Christofolini","doi":"10.61622/rbgo/2026rbgo30","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity to high levels of progesterone, with an as-yet unknown etiology. The objective of this study is to gather epidemiological data on patients with APD at an outpatient dermatology clinic.</p><p><strong>Methods: </strong>Medical records of patients diagnosed with APD, from menarche to menopause, seen at the dermatology clinic between 2004 and 2020 were reviewed.</p><p><strong>Results: </strong>Thirteen patients with APD were included. The mean age of symptom onset among APD patients was 24 years. The most prevalent clinical manifestation was urticaria, and the most common associated symptom was pruritus. The perimenstrual period was the most frequent aggravating factor, reported in 100% of cases. The intradermal progesterone test and autologous serum skin test were positive in approximately 60% of cases.</p><p><strong>Conclusion: </strong>Autoimmune progesterone dermatitis is an important differential diagnosis in female patients with dermatitis and should be considered during clinical evaluations.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"48 ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399379/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.61622/rbgo/2026rbgo30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Objective: Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity to high levels of progesterone, with an as-yet unknown etiology. The objective of this study is to gather epidemiological data on patients with APD at an outpatient dermatology clinic.
Methods: Medical records of patients diagnosed with APD, from menarche to menopause, seen at the dermatology clinic between 2004 and 2020 were reviewed.
Results: Thirteen patients with APD were included. The mean age of symptom onset among APD patients was 24 years. The most prevalent clinical manifestation was urticaria, and the most common associated symptom was pruritus. The perimenstrual period was the most frequent aggravating factor, reported in 100% of cases. The intradermal progesterone test and autologous serum skin test were positive in approximately 60% of cases.
Conclusion: Autoimmune progesterone dermatitis is an important differential diagnosis in female patients with dermatitis and should be considered during clinical evaluations.
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