Long Non-Coding RNAs: Allies and Enemies of HIV Infection.

IF 1.5 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2026-04-01 DOI:10.32607/actanaturae.27881

T F Kikhai, A V Mashkovskaia, T S Oretskaya, Y Y Agapkina, M B Gottikh

引用次数: 0

Abstract

significant impact on the pathogenesis of viral infections by acting as both positive and negative regulators of viral gene expression. This review summarizes the available data on lncRNAs associated with human immunodeficiency virus type 1 (HIV-1). LncRNAs can regulate both the active replication cycle and the latent phase of the HIV-1 infection, during which the integrated proviral DNA remains transcriptionally silent. Moreover, lncRNAs may serve as diagnostic markers and are potential therapeutic targets. A deeper understanding of the intricate interactions between lncRNAs and HIV-1 is essential for developing innovative treatments for the HIV infection and the associated acquired immunodeficiency syndrome (AIDS).

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长链非编码rna: HIV感染的盟友和敌人。

作为病毒基因表达的阳性和阴性调节因子，对病毒感染的发病机制产生重大影响。本文综述了与人类免疫缺陷病毒1型（HIV-1）相关的lncrna的现有数据。LncRNAs可以调节HIV-1感染的活性复制周期和潜伏期，在此期间，整合的前病毒DNA保持转录沉默。此外，lncrna可以作为诊断标记物和潜在的治疗靶点。深入了解lncrna与HIV-1之间复杂的相互作用对于开发针对HIV感染和相关获得性免疫缺陷综合征（AIDS）的创新治疗方法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.