Associations of serum cotinine and dietary inflammatory and antioxidant profiles with appendicular skeletal muscle mass in US adults: A cross-sectional study of data from NHANES 2011-2018.
IF 2.4 4区 医学Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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引用次数: 0
Abstract
Introduction: Tobacco exposure accelerates biological aging, but its specific association with appendicular skeletal muscle mass - and the potential modifying role of dietary patterns - remains incompletely characterized. This study aimed to investigate the association between serum cotinine and appendicular skeletal muscle mass index (ASMI), and to evaluate the mediating and modifying roles of dietary inflammatory and antioxidant profiles.
Methods: This secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 included 10291 US adults. Serum cotinine and dual-energy X-ray absorptiometry-derived ASMI were measured. Dietary quality was evaluated using the Dietary Inflammatory Index (DII) and Composite Dietary Antioxidant Index (CDAI). Associations were evaluated using multivariable survey-weighted generalized linear models, restricted cubic splines (RCS), and mediation analyses.
Results: In fully adjusted models, higher log10-transformed serum cotinine was independently associated with decreased ASMI (β= -0.02; 95% CI: -0.03 - -0.01; p=0.02). RCS analysis revealed a significant non-linear association (p for non-linearity <0.05). Mediation analyses demonstrated that DII and CDAI accounted for 30.6% and 13.3% of the total association, respectively. Furthermore, this inverse association was pronounced among participants with pro-inflammatory diets (β= -0.08, 95% CI: -0.156 - -0.004, p<0.001) but was attenuated and no longer statistically significant among those consuming anti-inflammatory and antioxidant-rich diets.
Conclusions: Higher serum cotinine is independently associated with decreased ASMI. This association is partially mediated by dietary inflammatory and antioxidant profiles, and is significantly modified by overall dietary quality. Optimizing nutritional profiles may offer a potential strategy to mitigate tobacco-associated skeletal muscle depletion, though prospective validation is warranted.
期刊介绍：
Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community.
The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.
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