Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010–2020

IF 2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2026-07-23 DOI:10.1002/bdr2.70092

Kelley Raines, Ashrita Rau, Reese Clark, Kate R. Woodworth, Van T. Tong, David Sugerman, Tatiana M. Lanzieri

{"title":"Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010–2020","authors":"Kelley Raines, Ashrita Rau, Reese Clark, Kate R. Woodworth, Van T. Tong, David Sugerman, Tatiana M. Lanzieri","doi":"10.1002/bdr2.70092","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Little is known about routine testing practices and diagnosis of congenital cytomegalovirus (cCMV) infection in newborns admitted to neonatal intensive care units (NICUs) across the United States. We assessed demographics and clinical signs associated with cCMV testing and diagnosis in newborns admitted to US NICUs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We analyzed Pediatrix Clinical Data Warehouse data, comprising 840,988 newborns admitted to 389 NICUs in 35 states during 2010–2020. We defined cCMV testing as culture or PCR performed on urine, saliva, blood, or cerebrospinal fluid collected within 21 days of life, and a positive result (except in saliva) as cCMV infection diagnosis. Logistic regression models examined associations between clinical signs and cCMV testing and diagnosis separately, adjusting for region, birth year, and prematurity.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 10,033 (1.2%) newborns tested (67.7% by culture; 79.8% using urine), 559 (5.6%) were diagnosed with cCMV infection. During 2010–2020, among those tested, the proportion with ≤ 1 clinical sign increased from 12.9% to 32.0%. Hepatosplenomegaly, petechiae, microcephaly, hepatitis, thrombocytopenia, chorioretinitis, and intracranial calcifications were associated with increased odds of both cCMV testing and diagnosis, with varying specificity.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Despite low CMV testing rates in the NICU, a shift toward testing newborns with fewer clinical signs occurred over time.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":"118 7","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.70092","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Little is known about routine testing practices and diagnosis of congenital cytomegalovirus (cCMV) infection in newborns admitted to neonatal intensive care units (NICUs) across the United States. We assessed demographics and clinical signs associated with cCMV testing and diagnosis in newborns admitted to US NICUs.

Methods

We analyzed Pediatrix Clinical Data Warehouse data, comprising 840,988 newborns admitted to 389 NICUs in 35 states during 2010–2020. We defined cCMV testing as culture or PCR performed on urine, saliva, blood, or cerebrospinal fluid collected within 21 days of life, and a positive result (except in saliva) as cCMV infection diagnosis. Logistic regression models examined associations between clinical signs and cCMV testing and diagnosis separately, adjusting for region, birth year, and prematurity.

Results

Among 10,033 (1.2%) newborns tested (67.7% by culture; 79.8% using urine), 559 (5.6%) were diagnosed with cCMV infection. During 2010–2020, among those tested, the proportion with ≤ 1 clinical sign increased from 12.9% to 32.0%. Hepatosplenomegaly, petechiae, microcephaly, hepatitis, thrombocytopenia, chorioretinitis, and intracranial calcifications were associated with increased odds of both cCMV testing and diagnosis, with varying specificity.

Conclusions

Despite low CMV testing rates in the NICU, a shift toward testing newborns with fewer clinical signs occurred over time.

查看原文本刊更多论文

先天性巨细胞病毒在新生儿重症监护病房的新生儿，美国，2010-2020。

导语：美国新生儿重症监护病房（NICUs）新生儿先天性巨细胞病毒（cCMV）感染的常规检测方法和诊断知之甚少。我们评估了美国新生儿重症监护病房中与cCMV检测和诊断相关的人口统计学和临床体征。方法：我们分析了儿科临床数据仓库的数据，包括2010-2020年35个州389个新生儿重症监护病房的840,988名新生儿。我们将cCMV检测定义为对21天内收集的尿液、唾液、血液或脑脊液进行培养或PCR检测，阳性结果（唾液除外）为cCMV感染诊断。Logistic回归模型分别检验了临床体征与cCMV检测和诊断之间的关系，调整了地区、出生年份和早产情况。结果：在10033例（1.2%）新生儿中（67.7%通过培养，79.8%通过尿液），559例（5.6%）被诊断为cCMV感染。2010-2020年，在被检测人群中，临床症状≤1的比例从12.9%上升到32.0%。肝脾肿大、瘀点、小头畸形、肝炎、血小板减少症、绒毛膜视网膜炎和颅内钙化与cCMV检测和诊断的几率增加相关，且特异性不同。结论：尽管新生儿重症监护室的巨细胞病毒检测率较低，但随着时间的推移，对临床症状较少的新生儿的检测发生了转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.