Peng Du, Jing Yang, Chunjie Li, Kailai Lu, Jie Ban, Can Zhang, Chen Wang, Jingwei Zhang, Qinghua Sun, Yi Zhang, Lin Cai, Shuiyin Ding, Feng Liu, Shengli Li, Rongshan Li, Yanping Lyu, Jianlin Hu, Ting Liu, Chuanyu Gao, Yong Huo, Tiantian Li
{"title":"Quantifying the Health Benefits Linked to Reduced Traffic-Related PM2.5 Exposure on Acute Coronary Syndrome Incidence in China","authors":"Peng Du, Jing Yang, Chunjie Li, Kailai Lu, Jie Ban, Can Zhang, Chen Wang, Jingwei Zhang, Qinghua Sun, Yi Zhang, Lin Cai, Shuiyin Ding, Feng Liu, Shengli Li, Rongshan Li, Yanping Lyu, Jianlin Hu, Ting Liu, Chuanyu Gao, Yong Huo, Tiantian Li","doi":"10.1021/envhealth.5c00615","DOIUrl":null,"url":null,"abstract":"<p>The transportation sector powered by fossil fuels is\r\na significant\r\ncontributor to PM<sub>2.5</sub> pollution. Systematic evaluation of\r\ntraffic-related PM<sub>2.5</sub> on acute coronary syndrome (ACS)\r\nonset is not yet characterized, and the health benefits of reduced\r\ntraffic-related PM<sub>2.5</sub> and evidence-based mitigation strategies\r\nare currently absent. We investigated the association of ACS onset\r\nwith short-term traffic-related PM<sub>2.5</sub> exposure in a nationwide\r\ntime-stratified case-crossover study, using 627,828 ACS cases extracted\r\nfrom the China Cardiovascular Association. We evaluated the risks\r\nof ACS onset associated with traffic-related PM<sub>2.5</sub>, calculated\r\nthe attributable onsets, and then conducted cluster analysis using\r\nthe K-means algorithm to identify priority cities for emission reduction.\r\nWe found a robust association between traffic-related PM<sub>2.5</sub> and ACS onset, i.e., an increased risk of 2.39% (95% CI: 1.79–3.00%)\r\nfor same-day (lag 0) PM<sub>2.5</sub> per 10 μg/m<sup>3</sup> increase. The greatest health benefits due to a 1 μg/m<sup>3</sup> PM<sub>2.5</sub> reduction were achieved by traffic-related\r\nPM<sub>2.5</sub>, reaching 10,267 (95%CI: 4503–16,063) onsets\r\nper year. In addition, three obvious categories were clustered, and\r\ntraffic-polluted cities were highlighted (cluster 2, not belonging\r\nto megacities), with high emissions and concentrations of traffic-related\r\nPM<sub>2.5</sub>. Therefore, intensified efforts to mitigate traffic-related\r\nPM<sub>2.5</sub> emissions should be promoted, and the prioritization\r\nof emission reduction strategies in these traffic-polluted cities\r\nis imperative for safeguarding public health.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 7","pages":"1545–1555"},"PeriodicalIF":8.8000,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment & Health","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/envhealth.5c00615","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The transportation sector powered by fossil fuels is
a significant
contributor to PM2.5 pollution. Systematic evaluation of
traffic-related PM2.5 on acute coronary syndrome (ACS)
onset is not yet characterized, and the health benefits of reduced
traffic-related PM2.5 and evidence-based mitigation strategies
are currently absent. We investigated the association of ACS onset
with short-term traffic-related PM2.5 exposure in a nationwide
time-stratified case-crossover study, using 627,828 ACS cases extracted
from the China Cardiovascular Association. We evaluated the risks
of ACS onset associated with traffic-related PM2.5, calculated
the attributable onsets, and then conducted cluster analysis using
the K-means algorithm to identify priority cities for emission reduction.
We found a robust association between traffic-related PM2.5 and ACS onset, i.e., an increased risk of 2.39% (95% CI: 1.79–3.00%)
for same-day (lag 0) PM2.5 per 10 μg/m3 increase. The greatest health benefits due to a 1 μg/m3 PM2.5 reduction were achieved by traffic-related
PM2.5, reaching 10,267 (95%CI: 4503–16,063) onsets
per year. In addition, three obvious categories were clustered, and
traffic-polluted cities were highlighted (cluster 2, not belonging
to megacities), with high emissions and concentrations of traffic-related
PM2.5. Therefore, intensified efforts to mitigate traffic-related
PM2.5 emissions should be promoted, and the prioritization
of emission reduction strategies in these traffic-polluted cities
is imperative for safeguarding public health.
期刊介绍：
Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health
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