Favorable clinical outcome of recurrent deep chest wall infection caused by pan-resistant Klebsiella pneumoniae treated with cefotaxime plus polymyxin B: a case report.

IF 2.4 4区医学 Q2 PARASITOLOGY

Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI:10.1590/0037-8682-0088-2026

Sophia Aléo Bomfim, José Eduardo Souza Echeverria, Ruana Carolina Cabral da Silva, Andyane Freitas Tetila, Andressa Leite Ferraz de Melo, Gleyce Hellen de Almeida de Souza, Cleide Adriane Signor Tirloni, Simone Simionatto

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引用次数: 0

Abstract

This case report describes a 43-year-old man admitted in November 2024 with recurrent deep anterior chest wall and thoracoabdominal soft-tissue infection caused by Klebsiella pneumoniae. Multidrug-resistant K. pneumoniae was isolated in December 2024. From January to April 2025, the patient required prolonged hospitalization, repeated debridements, and skin grafting, complicated by flap infection, acute kidney injury, and ICU admission. After initial improvement with polymyxin B and tigecycline, a severe recurrent infection caused by pan-resistant K. pneumoniae occurred in June 2025. Given the limited therapeutic options, treatment was changed to cefotaxime plus polymyxin B, leading to complete clinical recovery, which was later confirmed by in vitro synergy results.

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头孢噻肟联合多粘菌素B治疗泛耐药肺炎克雷伯菌复发性深胸壁感染1例临床效果良好。

本病例报告描述了一名43岁男性，于2024年11月因肺炎克雷伯菌引起的复发性深前胸壁和胸腹软组织感染入院。2024年12月分离出耐多药肺炎克雷伯菌。患者于2025年1月至4月长期住院，多次清创、植皮，并发皮瓣感染、急性肾损伤，住院ICU。在使用多粘菌素B和替加环素初步改善后，2025年6月发生了由泛耐药肺炎克雷伯菌引起的严重复发感染。在治疗方案有限的情况下，将治疗改为头孢噻肟加多粘菌素B，临床完全恢复，随后通过体外协同作用结果证实。

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来源期刊

Revista da Sociedade Brasileira de Medicina Tropical 医学-热带医学

CiteScore

3.40

自引率

10.00%

发文量

195

审稿时长

3-8 weeks

期刊介绍： The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.