To Investigate the Effect of Combined Use of 0.01% Atropine and 2% Carteolol Hydrochloride Eye Drops on Early-Onset Myopic Control in Western Chinese Children.
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引用次数: 0
Abstract
Purpose: To evaluate the inhibitory role of 0.01% atropine combined with 2% carteolol hydrochloride on myopia progression in children aged 3-8 years in western China.
Methods: A total of 78 myopic children (spherical equivalent refraction from -2.00D to -8.00D) were initially assigned based on parental willingness to a control group (artificial tears (Hialid®) once nightly) or a treatment group. The treatment group was then randomly divided into an atropine group (0.01% atropine + artificial tears) and a combination group (0.01% atropine +2% carteolol hydrochloride). Spherical equivalent (SE), axial length (AL), and intraocular pressure (IOP) were measured at baseline and 3, 6 months. Chi-square and Kruskal-Wallis tests, adjusted by multivariate regression and standardized mean differences (SMD), were applied. Analysis of Covariance (ANCOVA) addressed minor baseline variations. Repeated-measures analysis of variance evaluated ocular parameters across the three groups to assess the effect of IOP-lowering drugs on delaying myopia progression.
Results: Both treatment groups showed significantly reduced SE and AL progression at 3 and 6 months (all p < 0.001). At 6 months, the combination group exhibited significantly smaller AL increase (0.09 ± 0.10 mm) and SE progression (-0.09 ± 0.12 D) than the atropine group (AL: 0.47 ± 0.18 mm; SE: -0.51 ± 0.18 D) and control group (AL: 0.99 ± 0.16 mm; SE: -1.03 ± 0.15 D; all p < 0.001). IOP decreased in the combination group (-1.75 ± 4.24 mmHg) but increased in the other groups. Adverse reaction rates were comparable between groups (p > 0.05).
Conclusion: 0.01% atropine combined with 2% carteolol hydrochloride safely and effectively inhibits myopia progression in children with early-onset myopia.
期刊介绍：
Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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