Malignancy rates in surgically managed indeterminate thyroid nodules (Thy3a and Thy3f) in the UK National Health Service: a systematic review.

IF 1.1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2026-07-22 DOI:10.1017/S0022215126105489

Alexandros Poutoglidis, Stavros Savvakis, Kanishka Rao, Theofano Tikka, Georgios Oikonomou, Arun Takhar, Tunde Odutoye, Umair Ashfaq, George Paraskevas, Nikolaos Lazaridis, Nectarios Galanis, Chrysanthos Chrysanthou, Xanthippi Partalidou, Enyi Ofo

{"title":"Malignancy rates in surgically managed indeterminate thyroid nodules (Thy3a and Thy3f) in the UK National Health Service: a systematic review.","authors":"Alexandros Poutoglidis, Stavros Savvakis, Kanishka Rao, Theofano Tikka, Georgios Oikonomou, Arun Takhar, Tunde Odutoye, Umair Ashfaq, George Paraskevas, Nikolaos Lazaridis, Nectarios Galanis, Chrysanthos Chrysanthou, Xanthippi Partalidou, Enyi Ofo","doi":"10.1017/S0022215126105489","DOIUrl":null,"url":null,"abstract":"Objectives: Our systematic review assesses the observed cancer rate among surgically treated indeterminate thyroid nodules (Thy3a and Thy3f) to determine if current management remains appropriate.Methods: A systematic search was performed for retrospective and prospective studies published after 2008 from National Health Service (NHS) hospitals. The primary outcome was the thyroid malignancy rate among surgically managed indeterminate nodules. Chi-squared analysis and Quality Assessment of Diagnostic Accuracy Studies 2 were employed for statistical and quality assessment, respectively.Results: Eighteen studies met our inclusion criteria (3,195 cases). The reported malignancy rate was 25.16 per cent for Thy3a and 26.27 per cent for Thy3f cytology in patient underwent diagnostic surgery. However, statistical analysis (p = 0.518) demonstrated no statistically significant difference in these cancer rates.Conclusion: The similar cancer rates between Thy3a and Thy3f nodules observed in our review challenge the current management strategies for these two subcategories. Future prospective studies are needed to validate these findings and address the existing limitations.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"1-7"},"PeriodicalIF":1.1000,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Laryngology and Otology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0022215126105489","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Our systematic review assesses the observed cancer rate among surgically treated indeterminate thyroid nodules (Thy3a and Thy3f) to determine if current management remains appropriate.

Methods: A systematic search was performed for retrospective and prospective studies published after 2008 from National Health Service (NHS) hospitals. The primary outcome was the thyroid malignancy rate among surgically managed indeterminate nodules. Chi-squared analysis and Quality Assessment of Diagnostic Accuracy Studies 2 were employed for statistical and quality assessment, respectively.

Results: Eighteen studies met our inclusion criteria (3,195 cases). The reported malignancy rate was 25.16 per cent for Thy3a and 26.27 per cent for Thy3f cytology in patient underwent diagnostic surgery. However, statistical analysis (p = 0.518) demonstrated no statistically significant difference in these cancer rates.

Conclusion: The similar cancer rates between Thy3a and Thy3f nodules observed in our review challenge the current management strategies for these two subcategories. Future prospective studies are needed to validate these findings and address the existing limitations.

查看原文本刊更多论文

英国国家卫生服务中心手术治疗的不确定甲状腺结节（Thy3a和Thy3f）的恶性率系统回顾。

目的：我们的系统综述评估了手术治疗的不确定甲状腺结节（Thy3a和Thy3f）的观察癌率，以确定当前的治疗是否仍然合适。方法：系统检索2008年以后国家卫生服务（NHS）医院发表的回顾性和前瞻性研究。主要结局是手术治疗的不确定结节中甲状腺恶性肿瘤的发生率。统计学和质量评价分别采用卡方分析和诊断准确性研究2的质量评价。结果：18项研究（3195例）符合我们的纳入标准。在接受诊断性手术的患者中，Thy3a细胞学报告的恶性率为25.16%，Thy3f细胞学报告的恶性率为26.27%。然而，统计学分析（p = 0.518）显示这些癌症发病率无统计学意义。结论：在我们的综述中观察到的Thy3a和Thy3f结节之间相似的癌症发生率对这两个亚类的当前管理策略提出了挑战。需要未来的前瞻性研究来验证这些发现并解决现有的局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.