A call for unified use of human aminoacyl-tRNA synthetase (ARS) gene nomenclature

IF 3 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2026-08-24 Epub Date: 2026-07-21 DOI:10.1002/1873-3468.70418

Anthony Antonellis, Maximiliano Barrientos, Eva Bensasson, Teri DeClercq, Pablo Garrigós, Rachel Heilmann, Rita Horvath, Desiree Magee, Angelica Moresco, Ashley Rowland, Ingrid Vallee, Rebecca Alexander, Haissi Cui, Ita Gruić-Sovulj, Tamara L. Hendrickson, Sunghoon Kim, Jiqiang Ling, Susan A. Martinis, Karin Musier-Forsyth, Xiang-Lei Yang, Ilka U. Heinemann, Lluis Ribas de Pouplana

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引用次数: 0

Abstract

Aminoacyl-tRNA synthetases (ARSs) are a family of enzymes that attach amino acids to tRNAs. To date, all 37 human ARS genes have been implicated in genetic diseases, affecting over a thousand patients worldwide. At the 2025 Federation of European Biochemical Societies (FEBS) Special Meeting ‘Expanding Frontiers in Aminoacyl-tRNA Synthetase Research’, patients, families, and advocacy groups communicated the need for a unified approach for reporting on ARS gene names and associated conditions in the scientific literature. This request stemmed from the current use of multiple nomenclature systems and the desire of these individuals to rapidly identify published data on specific ARS genes. Here, we summarize ARS gene nomenclature and request that the scientific community adhere to a single nomenclature system.

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呼吁统一使用人氨基酰基trna合成酶（ARS）基因命名法。

氨基酰基trna合成酶（ARSs）是一个将氨基酸连接到trna上的酶家族。迄今为止，所有37种人类ARS基因都与遗传疾病有关，影响了全世界一千多名患者。在2025年欧洲生化学会联合会（FEBS）特别会议“拓展氨基酰基- trna合成酶研究的前沿”上，患者、家属和倡导团体传达了在科学文献中报告ARS基因名称和相关条件的统一方法的必要性。这一要求源于目前使用的多种命名系统，以及这些人希望快速识别有关特定ARS基因的已发表数据。在此，我们总结了ARS基因命名法，并要求科学界坚持一个单一的命名系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.