{"title":"NMDA Receptor-Associated Encephalitis and Renal Failure - A Unique Association.","authors":"Komal Bohra, Rukmini Mridula, Sruthi Kola, Rupam Borgohain","doi":"10.4103/neurol-india.Neurol-India-D-25-00466","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>N-methyl-D-aspartate (NMDA) receptor encephalitis stands as the most common form of autoimmune encephalitis in young adults, characterized by a spectrum of distressing symptoms such as seizures, behavioral disruptions, autonomic dysfunction, and memory impairment. We present a noteworthy case involving a young adult male exhibiting seizures and renal failure, initially prompting an evaluation for vasculitis, hyperuricemia-induced acute kidney injury (AKI), and rhabdomyolysis-induced AKI. However, subsequent findings revealed the presence of NMDA receptor antibodies, and a renal biopsy confirmed tubulointerstitial nephritis. This case sheds light on the association between renal failure and NMDA receptor antibody-associated encephalitis, marking a rare instance in our knowledge.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"678-681"},"PeriodicalIF":0.8000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology India","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00466","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: N-methyl-D-aspartate (NMDA) receptor encephalitis stands as the most common form of autoimmune encephalitis in young adults, characterized by a spectrum of distressing symptoms such as seizures, behavioral disruptions, autonomic dysfunction, and memory impairment. We present a noteworthy case involving a young adult male exhibiting seizures and renal failure, initially prompting an evaluation for vasculitis, hyperuricemia-induced acute kidney injury (AKI), and rhabdomyolysis-induced AKI. However, subsequent findings revealed the presence of NMDA receptor antibodies, and a renal biopsy confirmed tubulointerstitial nephritis. This case sheds light on the association between renal failure and NMDA receptor antibody-associated encephalitis, marking a rare instance in our knowledge.
摘要：n -甲基- d -天冬氨酸（NMDA）受体脑炎是年轻人中最常见的自身免疫性脑炎，其特征是一系列令人痛苦的症状，如癫痫发作、行为中断、自主神经功能障碍和记忆障碍。我们报告了一个值得注意的病例，涉及一名年轻的成年男性，表现出癫痫发作和肾功能衰竭，最初促使对血管炎、高尿酸血症诱导的急性肾损伤（AKI）和横纹肌溶解诱导的AKI进行评估。然而，随后的结果显示NMDA受体抗体的存在，肾活检证实了小管间质性肾炎。本病例揭示了肾衰竭与NMDA受体抗体相关性脑炎之间的关系，这是我们所知的罕见病例。
期刊介绍：
Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues.
This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.
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