Development of a Multifunctional Delivery System Based on Calcium Carbonate Nanoparticles for Combined Radiotherapy of Melanoma

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2026-07-21 DOI:10.1134/S2635167625602050

D. R. Akhmetova, V. A. Rusakova, D. A. Matveev, S. A. Shipilovskikh, A. S. Timin

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Abstract

A novel multifunctional delivery system based on calcium carbonate nanoparticles has been developed for combination radiotherapy of melanoma. Encapsulation protocols for a therapeutic compound have been successfully implemented, using potassium 1-amino-1,6-dioxo-6-(4-methoxyphenyl)-2-cyano-4-((3-(ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino)hexa-2,4-dien-3-olate, which has an antitumor effect, and the radioisotope radium-223 as an example. Controlled pH-dependent kinetics of drug release is demonstrated. The efficiency of radiolabeling with radium-223 was ~95.9 ± 3.1% with a high degree of activity retention in vitro (more than 90% after 144 h). The developed delivery system based on calcium carbonate nanoparticles demonstrated high biocompatibility with MDCK cells. The resulting radiopharmaceutical, in its “cold” modification, demonstrated dose-dependent cytotoxicity against B16-F10 melanoma cells, confirming the potential of this platform for subsequent use in combination radiotherapy for melanoma.

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基于碳酸钙纳米颗粒的黑色素瘤联合放疗多功能输送系统的研制

一种基于碳酸钙纳米颗粒的新型多功能输送系统已被开发用于黑色素瘤的联合放疗。一种治疗性化合物的包封方案已经成功实施，以具有抗肿瘤作用的1-氨基-1,6-二氧基-6-（4-甲氧基苯基）-2-氰基-4-（（3-（乙氧基羰基）-4,5,6,7-四氢苯并[b]噻吩-2-基）氨基）六-2,4-二烯-3-酸钾和放射性同位素镭-223为例。药物释放的受控ph依赖动力学被证明。镭-223的放射性标记效率为~95.9±3.1%，体外活性保留率高（144 h后保留率超过90%）。基于碳酸钙纳米颗粒的递送系统显示出与MDCK细胞的高生物相容性。由此产生的放射性药物，在其“冷”修饰中，显示出对B16-F10黑色素瘤细胞的剂量依赖性细胞毒性，证实了该平台随后用于黑色素瘤联合放疗的潜力。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.