Ligand relay catalysis enables asymmetric migratory dearomative annulation of N-heteroarenes.

IF 18.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2026-07-20 DOI:10.1038/s41467-026-75769-0

Zhiyong Song,Xinyu Li,Xinchen Wang,Asif Rasool,You Wang,Shaolin Zhu

引用次数: 0

Abstract

Chiral N-spiroheterocycles are privileged yet synthetically challenging scaffolds for ligands, functional materials, and drug discovery. Here we show a cobalt-catalyzed asymmetric migratory dearomative annulation of electron-deficient N‑heteroarenes for their construction. The success of this transformation hinges on a dynamic ligand relay catalysis strategy, wherein two distinct ligands work in tandem: one facilitates a 1,4-cobalt/hydride shift, and the other governs the enantioselective dearomative annulation, delivering chiral N-spiroheterocycles with high efficiency and selectivity.

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配体接力催化实现了n -杂芳烃的不对称迁移脱芳环化。

手性n -螺杂环是配体、功能材料和药物发现方面具有优势但具有合成挑战性的支架。在这里，我们展示了钴催化的不对称迁移脱芳环的缺电子N -杂芳烃的结构。这种转化的成功取决于动态配体接力催化策略，其中两种不同的配体串联起作用：一种促进1,4-钴/氢化物位移，另一种控制对映选择性脱芳环，以高效率和选择性提供手性n -螺杂环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.