Evaluation of pancreatic stump binding and ligation in reducing postoperative pancreatic fistula after distal pancreatectomy: a retrospective cohort study.

IF 2.4 3区医学 Q2 SURGERY

BMC Surgery Pub Date : 2026-07-18 DOI:10.1186/s12893-026-04052-2

Zi-Ang Jiang, Xiang-Yu Lu, Hang Deng, Xu Wang, Jian Xu, Jie Zhang, Yao Zhou, Jun Gong, Ke Dong, Yan Dai, Hao Zhang

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Abstract

Background: This study evaluates the efficacy of pancreatic stump binding and ligation (PSBL) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).

Methods: A retrospective cohort analysis included 217 patients undergoing DP between 2015 and 2022. Patients were classified into two groups: those receiving PSBL (B-Group, n = 96) and those without (NB-Group, n = 121). The primary outcome was incidence of clinically relevant POPF (Grade B/C).

Results: The B-Group demonstrated lower POPF rates (11.5% vs. 28.9%, P = 0.003) compared to the NB-Group, with grade B fistulas particularly reduced (P = 0.002). Multivariate analysis identified independent risk factors for POPF: BMI ≥ 28 kg/m² (OR = 14.105, P < 0.001), Preoperative Hypoalbuminemia (OR = 7.031, P < 0.001), Manual Method of Stump Closure (OR = 2.558, P = 0.020), and non-PSBL Technique (OR = 4.463, P < 0.001).

Conclusions: In this retrospective cohort, PSBL is a promising, feasible technique associated with reduced clinically relevant POPF incidence after DP. Given the retrospective design, these findings are hypothesis-generating and warrant prospective, multicenter validation.

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远端胰腺切除术后胰残端结扎减少胰瘘的评价：一项回顾性队列研究。

背景：本研究评价胰腺残端结扎术（PSBL）减少远端胰腺切除术（DP）后胰瘘（POPF）的疗效。方法：对2015年至2022年间217例DP患者进行回顾性队列分析。将患者分为两组：接受PSBL治疗组（b组，n = 96）和未接受PSBL治疗组（nb组，n = 121）。主要终点是临床相关POPF的发生率（B/C级）。结果：与nb组相比，B组的POPF发生率较低（11.5% vs. 28.9%, P = 0.003），其中B级瘘管特别减少（P = 0.002）。多因素分析确定了POPF的独立危险因素：BMI≥28 kg/m2 （OR = 14.105， P）。结论：在本回顾性队列中，PSBL是一种有希望的、可行的技术，与DP后临床相关的POPF发病率降低相关。鉴于回顾性设计，这些发现是假设产生和保证前瞻性，多中心验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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