Longitudinal Associations Between Inflammatory Markers at 12-Months and Three Core Symptoms of Depression at 12- and 24-Months After Colorectal Cancer Diagnosis: Results From the Population-Based PROFILES Registry.

IF 3.9 2区医学 Q2 ONCOLOGY

Psycho‐Oncology Pub Date : 2026-07-01 DOI:10.1002/pon.70555

Chris Hinnen, Floortje Mols, Dounya Schoormans

{"title":"Longitudinal Associations Between Inflammatory Markers at 12-Months and Three Core Symptoms of Depression at 12- and 24-Months After Colorectal Cancer Diagnosis: Results From the Population-Based PROFILES Registry.","authors":"Chris Hinnen, Floortje Mols, Dounya Schoormans","doi":"10.1002/pon.70555","DOIUrl":null,"url":null,"abstract":"Purpose: Depression is a heterogeneous construct comprising distinct symptom domains, including motivational anhedonia, consummatory anhedonia, and negative affect, commonly experienced by colorectal cancer (CRC) survivors. Inflammation has been implicated in depression, its association with specific depressive symptom domains in CRC survivors remains insufficiently characterized.Methods: CRC patients (n = 497) completed questionnaires assessing depressive symptoms 12- and 24-months post-diagnosis: motivational anhedonia (Multidimensional Fatigue Inventory), consummatory anhedonia (Hospital Anxiety and Depression Scale-depression), and negative affect (EORTC QLQ-C30, emotional functioning). Associations between 11 inflammatory markers (CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, IL-17A, IL-22, IFN-γ, sTNFRI, and sTNFRII) at 12-months and depressive symptoms at 12- and 24-months were examined using linear mixed models.Results: IL-1β (Est = 0.089, p = 0.003) and IFN-γ (Est = 0.067, p = 0.001) were associated with more consummatory anhedonia symptoms across time, and a small sTNFRI × time interaction was found (Est = 0.000, p = 0.007). Negative affect was associated with IL-1β (Est = -0.496, p < 0.001), IFN-γ (Est = -0.354, p < 0.001), and sTNFRI (Est = -0.003, p < 0.001). A significant IL-1α × time interaction was observed (Est = 0.250, p = 0.038) for motivational anhedonia.Conclusions: Most consistently IL-1β, IFN-γ, and sTNFRI was associated with greater consummatory anhedonia and more negative affect in CRC survivors. In addition, inflammatory correlates (IL-1α and sTNFRI) of motivational anhedonia and consummatory anhedonia changed over time. These findings suggest that selected inflammatory pathways may contribute to specific depressive symptom domains during colorectal cancer survivorship. Given the exploratory nature of the analyses, replication in independent cohorts is required before clinical implications can be drawn.","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 7","pages":"e70555"},"PeriodicalIF":3.9000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379931/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psycho‐Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pon.70555","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Depression is a heterogeneous construct comprising distinct symptom domains, including motivational anhedonia, consummatory anhedonia, and negative affect, commonly experienced by colorectal cancer (CRC) survivors. Inflammation has been implicated in depression, its association with specific depressive symptom domains in CRC survivors remains insufficiently characterized.

Methods: CRC patients (n = 497) completed questionnaires assessing depressive symptoms 12- and 24-months post-diagnosis: motivational anhedonia (Multidimensional Fatigue Inventory), consummatory anhedonia (Hospital Anxiety and Depression Scale-depression), and negative affect (EORTC QLQ-C30, emotional functioning). Associations between 11 inflammatory markers (CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, IL-17A, IL-22, IFN-γ, sTNFRI, and sTNFRII) at 12-months and depressive symptoms at 12- and 24-months were examined using linear mixed models.

Results: IL-1β (Est = 0.089, p = 0.003) and IFN-γ (Est = 0.067, p = 0.001) were associated with more consummatory anhedonia symptoms across time, and a small sTNFRI × time interaction was found (Est = 0.000, p = 0.007). Negative affect was associated with IL-1β (Est = -0.496, p < 0.001), IFN-γ (Est = -0.354, p < 0.001), and sTNFRI (Est = -0.003, p < 0.001). A significant IL-1α × time interaction was observed (Est = 0.250, p = 0.038) for motivational anhedonia.

Conclusions: Most consistently IL-1β, IFN-γ, and sTNFRI was associated with greater consummatory anhedonia and more negative affect in CRC survivors. In addition, inflammatory correlates (IL-1α and sTNFRI) of motivational anhedonia and consummatory anhedonia changed over time. These findings suggest that selected inflammatory pathways may contribute to specific depressive symptom domains during colorectal cancer survivorship. Given the exploratory nature of the analyses, replication in independent cohorts is required before clinical implications can be drawn.

查看原文本刊更多论文

结直肠癌诊断后12个月时炎症标志物与12个月和24个月时抑郁的三个核心症状之间的纵向关联：基于人群概况登记的结果

目的：抑郁症是一种异质性结构，包括不同的症状域，包括动机性快感缺乏、完满性快感缺乏和负面情绪，这是结直肠癌（CRC）幸存者普遍经历的。炎症与抑郁有关，但其与结直肠癌幸存者特定抑郁症状域的关联仍未充分表征。方法：CRC患者（n = 497）在诊断后12个月和24个月完成抑郁症状评估问卷：动机性快感缺乏症（多维疲劳量表）、完满性快感缺乏症（医院焦虑和抑郁量表-抑郁）和负面情绪（EORTC QLQ-C30，情绪功能）。采用线性混合模型检测12个月时11种炎症标志物（CRP、IL-1α、IL-1β、IL-6、IL-8、IL-10、IL-17A、IL-22、IFN-γ、sTNFRI和sTNFRII）与12个月和24个月时抑郁症状的相关性。结果：随着时间的推移，IL-1β (Est = 0.089, p = 0.003)和IFN-γ (Est = 0.067, p = 0.001)与更多的完满性快感缺失症状相关，并且发现sTNFRI与时间的小相互作用（Est = 0.000, p = 0.007）。结论：在结直肠癌幸存者中，IL-1β、IFN-γ和sTNFRI与更大的完满性快感缺乏症和更多的负面情绪相关。此外，炎性相关因子（IL-1α和sTNFRI）与动机性快感缺乏症和完成性快感缺乏症的关系也随时间变化。这些发现表明，在结直肠癌存活期间，选择的炎症途径可能有助于特定的抑郁症状域。考虑到分析的探索性，在得出临床意义之前，需要在独立队列中进行复制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Psycho‐Oncology 医学-心理学

CiteScore

6.30

自引率

8.30%

发文量

220

审稿时长

3-8 weeks

期刊介绍： Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.