{"title":"What changes in the therapeutic management of papillary thyroid carcinoma. Emerging evidence.","authors":"Apostolos Goropoulos","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The low mortality of papillary thyroid carcinoma (PTC) has led to progressively less aggressive therapeutic approaches according to the latest 2025 guidelines. However, morbidity associated with persistent disease and cervical lymph node metastases remains a significant clinical challenge. The presence of undetected \"occult\" metastases and the occurrence of nodal recurrences following apparently adequate treatment raise concerns regarding the effectiveness of current diagnostic and therapeutic strategies. Improving preoperative diagnostic accuracy in assessing both the extent and aggressiveness of the disease could play a decisive role in selecting the most appropriate surgical approach and the need for adjuvant radioactive iodine (RAI) therapy. Precise topographical localization of the tumor represents an additional risk factor that should be incorporated into therapeutic decision-making.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"36-42"},"PeriodicalIF":0.8000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hellenic journal of nuclear medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
The low mortality of papillary thyroid carcinoma (PTC) has led to progressively less aggressive therapeutic approaches according to the latest 2025 guidelines. However, morbidity associated with persistent disease and cervical lymph node metastases remains a significant clinical challenge. The presence of undetected "occult" metastases and the occurrence of nodal recurrences following apparently adequate treatment raise concerns regarding the effectiveness of current diagnostic and therapeutic strategies. Improving preoperative diagnostic accuracy in assessing both the extent and aggressiveness of the disease could play a decisive role in selecting the most appropriate surgical approach and the need for adjuvant radioactive iodine (RAI) therapy. Precise topographical localization of the tumor represents an additional risk factor that should be incorporated into therapeutic decision-making.
期刊介绍：
The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of
Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and
cover the scientific and professional interests of physicians, in the field of nuclear
medicine and in medicine in general. The journal may publish papers of nuclear
medicine and also papers that refer to related subjects as dosimetry, computer science,
targeting of gene expression, radioimmunoassay, radiation protection, biology, cell
trafficking, related historical brief reviews and other related subjects. Original papers
are preferred. The journal may after special agreement publish supplements covering
important subjects, dully reviewed and subscripted separately.
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