The Discovery Process Chemistry (DPC) Model: A Cross-Pharma Perspective

IF 3.3 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2026-08-21 Epub Date: 2026-07-17 DOI:10.1021/acs.oprd.6c00218

Joseph M. Bateman, Jonathan M. E. Hughes, Matthieu Jouffroy, Peter J. Lindsay-Scott, Thomas M. McGuire, Damien Valette, Hilmar Weinmann

引用次数: 0

Abstract

Discovery Process Chemistry (DPC) has emerged as a critical bridge between discovery chemistry and chemical development that allows more seamless progression of drug candidates to the clinic. DPC aims to accelerate projects by integrating SAR-enabling methodologies, scalable route design to inform later campaigns, and early material delivery. Case studies from MSD, Johnson & Johnson, and AstraZeneca highlight how this model can drive innovation and mitigate risks at the interface between medicinal and process chemistry groups. Keywords: discovery process, route scouting, early scale-up, and SAR enabling.

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发现过程化学（DPC）模型：一个跨制药的视角

发现过程化学（DPC）已成为发现化学和化学开发之间的关键桥梁，允许候选药物更无缝地进展到临床。DPC的目标是通过集成sar支持方法、可扩展路线设计以通知后期活动和早期材料交付来加速项目。来自默沙东、强生和阿斯利康的案例研究强调了这种模式如何在药物和工艺化学组之间的界面上推动创新并降低风险。关键词：发现过程、路由侦察、早期放大和SAR启用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.