Which Molecule Is Involved in the Nitrosation Reaction of Pharmaceuticals: NO or NO2?

IF 3.3 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2026-08-21 Epub Date: 2026-07-17 DOI:10.1021/acs.oprd.6c00108

Ryota Nomura, Hideyuki Sogo, Takuma Onai, Misako Iwazawa, Tomohiro Kaku, Osamu Uchikawa

引用次数: 0

Abstract

We have previously clearly identified atmospheric nitrogen oxides (NOx) as a key factor in nitrosamine contamination in pharmaceuticals. To implement more appropriate countermeasures, the nitrosation potential of nitrogen monoxide (NO) and nitrogen dioxide (NO₂)─the primary components of NOx─was evaluated using short-term and long-term gas flow model experiments. The results revealed that NO₂ is required for the nitrosation reaction to occur.

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哪个分子参与了药物的亚硝化反应：NO还是NO2？

我们以前已经明确地确定大气氮氧化物（NOx）是药品中亚硝胺污染的关键因素。为了实施更合适的对策，利用短期和长期气体流动模型实验评估了NOx的主要成分——一氧化氮（NO）和二氧化氮（NO2）的亚硝化电位。结果表明，硝化反应的发生需要NO2的参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.