[Tryptophan metabolism: a key player in cardiometabolic diseases].

IF 0.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

M S-medecine Sciences Pub Date : 2026-06-01 Epub Date: 2026-07-17 DOI:10.1051/medsci/2026094

Mouna Chajadine, Ludivine Laurans, Soraya Taleb

引用次数: 0

Abstract

Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.

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[色氨酸代谢：心脏代谢疾病的关键角色]。

色氨酸（Trp）是一种必需氨基酸，在代谢、炎症、免疫和能量平衡中起着核心作用。它主要通过犬尿氨酸、吲哚和血清素途径代谢，根据生理和组织环境产生具有保护或有害作用的代谢物。这些通路的失调会导致肥胖、糖尿病和心血管疾病。了解这些机制为个性化的营养和治疗策略铺平了道路，以预防和管理心脏代谢疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

M S-medecine Sciences 医学-医学：研究与实验

CiteScore

0.80

自引率

14.30%

发文量

182

审稿时长

4-8 weeks

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