Effect of Hyaluronic Acid on Palatal Wound Healing—A Randomized Crossover Clinical Trial

IF 5.9 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2026-10-07 Epub Date: 2026-07-16 DOI:10.1111/clr.70159

Madeleine Dahi, Sara Amash, Kristina Bertl, Florian Beck, Patrick Heimel, Andreas Stavropoulos

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引用次数: 0

Abstract

Aim

To assess the effect of a hyaluronic acid (HyA) containing gel on patient-related outcomes (PRO) and wound healing after palatal punch-biopsy representing a free gingival graft.

Material and Methods

A punch-biopsy (6 mm diameter, 2 mm thickness) was harvested from one side of the palate at Day 0 and from the contralateral side at Day 21. Sites were randomly allocated to either 0.3% HyA containing gel (test) or sterile saline solution (control), professionally applied after harvesting and then self-applied three times/day for 7 days. Up to 21 days PRO-related questionnaires were answered and intraoral scans and photographs recorded to assess wound re-epithelialization, tissue refill, and color match.

Results

Eighteen of 25 recruited participants were analyzed. Pain perception, difficulties with eating/drinking, and taste alterations significantly decreased over time and were hardly experienced after Day 7 in both groups (p > 0.05). Participants reported significantly more often a positive experience after applying HyA compared to placebo, that is, in 8 versus 1 out of 18 cases. The residual wound area was significantly smaller in the test compared to control group at Day 7, and cases with a thicker palatal tissue showed tendency for faster re-epithelialization.

Conclusion

Despite the potential limitations of the present study (i.e., possibility of a carryover effect, questionable blinding of the participants), repeated local application of a 0.3% HyA containing gel appears to only accelerate re-epithelialization in an open palatal wound and provide a positive experience after application, but it did not improve any PRO in such small-sized wounds compared to sterile saline application.

Trial Registration

ClinicalTrials.gov identifier: NCT05099718

查看原文本刊更多论文

透明质酸对腭创面愈合的影响——一项随机交叉临床试验

目的评估含透明质酸（HyA）凝胶对游离牙龈移植术后患者相关预后（PRO）和伤口愈合的影响。材料和方法在第0天和第21天分别从腭的一侧和对侧采集穿孔活检（直径6 mm，厚度2 mm）。试验点随机分配到含有0.3% HyA的凝胶（试验）或无菌生理盐水溶液（对照），收割后专业应用，然后自行应用，每天三次，持续7天。研究人员回答了长达21天的PRO相关问卷，并记录了口腔内扫描和照片，以评估伤口的再上皮化、组织填充和颜色匹配。结果25名被招募的参与者中有18人被分析。疼痛感知、饮食困难和味觉改变随着时间的推移显著下降，两组患者在第7天后几乎没有经历过疼痛（p > 0.05）。与安慰剂相比，使用HyA后，参与者报告的积极体验明显更多，即18例中有8例比1例。在第7天，与对照组相比，试验组的残余伤口面积明显更小，腭组织更厚的病例显示出更快的再上皮化趋势。结论：尽管本研究存在潜在的局限性（即，可能存在传递效应，参与者可能会失明），但反复局部应用含有0.3% HyA的凝胶似乎只会加速开放腭伤口的再上皮化，并在应用后提供积极的体验，但与无菌生理盐水应用相比，它并没有改善这种小伤口的PRO。试验注册ClinicalTrials.gov标识符：NCT05099718

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.