Macrophages are constitutive architects of tissue integrity

IF 47.1 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2026-07-17 DOI:10.1038/s41577-026-01334-x

Miriam Merad

引用次数: 0

Abstract

The lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of macrophages and offers untapped therapeutic targets in these cells.

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巨噬细胞是组织完整性的基本建筑师

炎性、防御导向、单核细胞来源的巨噬细胞和致力于组织维持的常驻巨噬细胞之间的谱系差异使巨噬细胞的原始功能受到质疑，并为这些细胞提供了尚未开发的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.