The tip of the iceberg: Morbidity in polycystic ovary syndrome in reproductive-age women

IF 3.4 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2026-11-01 Epub Date: 2026-07-15 DOI:10.1016/j.ando.2026.102598

Blandine Courbiere, Eugénie Micolon, Appoline Zimmermann, Pascal Auquier, Julie Berbis, Sandrine Loubière

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引用次数: 0

Abstract

Context

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women, but its true burden remains underestimated due to diagnostic variability and underreporting.

Objective

To estimate the morbidities in reproductive-age women identified with a diagnosis of PCOS in the French national health data system.

Methods

We conducted a retrospective cohort study using the French national health data system (SNDS) to identify reproductive-age women (18–43 years) diagnosed with PCOS (ICD-10 code E28.2) between 2014 and 2022. Morbidity data were assessed in 2022 and compared with an age-matched control group of women without PCOS in the same year. Specific comorbidities were identified using a set of algorithms applied to the system's data and based on both ICD-10 codes and medical acts and drug use. Logistic regression models were used to compare comorbidity rates, with odds ratios adjusted for age and social deprivation.

Results

We identified 21,144 women with PCOS in the health data system. Median age was 35 years [IQR: 29–39]. Compared with the general female population, women with PCOS had significantly higher rates of infertility (adjusted odds ratio (aOR) = 24.35), gestational diabetes (aOR = 1.64), type 2 diabetes (aOR 14.71), pulmonary embolism (aOR = 2.04), arterial hypertension (aOR 5.86), acute stroke (aOR= 2.39), cardioneurovascular disease (aOR 2.12) and psychiatric disorders (aOR = 1.66).

Conclusions

Given the high morbidity among women identified with PCOS on ICD-10 code E28.2, improved diagnostic algorithms are needed to better identify PCOS cases in health databases and assess their public health implications.

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冰山一角：多囊卵巢综合征在育龄妇女中的发病率。

背景：多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病，但由于诊断的多变性和漏报，其真正的负担仍然被低估。目的：估计法国国家卫生数据系统中诊断为多囊卵巢综合征的育龄妇女的发病率。方法：采用法国国家健康数据系统（SNDS）对2014年至2022年间诊断为多囊卵巢综合征（ICD-10代码E28.2）的育龄妇女（18-43岁）进行回顾性队列研究。发病率数据于2022年进行评估，并与同年无PCOS的同龄对照组进行比较。使用一套应用于系统数据的算法，并基于ICD-10代码和医疗行为和药物使用，确定了具体的合并症。使用逻辑回归模型比较合并症发生率，并根据年龄和社会剥夺调整比值比。结果：我们在健康数据系统中确定了21,144名多囊卵巢综合征妇女。中位年龄35岁[IQR: 29-39]。与普通女性人群相比，PCOS女性的不孕症（调整优势比(aOR)=24.35）、妊娠期糖尿病（aOR=1.64）、2型糖尿病（aOR 14.71）、肺栓塞（aOR=2.04）、动脉高血压（aOR 5.86）、急性卒中（aOR= 2.39）、心血管疾病（aOR 2.12）和精神疾病（aOR= 1.66）的发生率显著高于普通女性人群。结论：鉴于ICD-10代码E28.2中PCOS女性的高发病率，需要改进诊断算法以更好地识别健康数据库中的PCOS病例并评估其公共卫生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.