Ethylenediaminedisuccinic Acid: A Bio-Friendly Chelating Agent for Smear Layer Removal, Dentine Integrity, and Sealer Penetration.

IF 1.7 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2026-07-15 DOI:10.1111/aej.70099

Deniz Yanık Nalbantoğlu, Burcu Yagmur, Elif Bolat

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引用次数: 0

Abstract

Although EDTA remains the gold standard, concerns regarding its toxicity/environmental persistence have driven the search for bio-friendly alternatives. We evaluated the effect of EDDS on microhardness, smear layer, and dentine penetration of canal sealer. Two hundred and fifteen single-rooted teeth with round morphology were used. Samples were treated with solutions for 3 min. Vickers microhardness was analysed. Final irrigation was performed: GroupET: 17%-EDTA; GroupED:15%-EDDS; GroupET/N:17%-EDTA +2.5%-NaOCl; GroupED/N:15%-EDDS +2.5%-NaOCl; GroupC:distilled-water. The smear layer was evaluated. Canals were obturated using epoxy-resin and bioceramic-sealer. Dentine penetration was analysed using confocal microscopy. One-way-ANOVA, Student's t-test, Fisher-Freeman-Halton-exact, and Wilcoxon signed-rank-test were applied. EDTA and EDDS affected microhardness, smear layer, and dentine penetration similarly (p > 0.05). Dentine penetration was higher with the bioceramic-sealer and was enhanced by NaOCl (p < 0.05). EDDS demonstrated similar results to EDTA and represents a potentially more bio-friendly chelating approach that may support more biologically/environmentally conscious irrigation strategies.

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乙二胺二琥珀酸：一种生物友好的螯合剂，用于去除涂抹层，牙本质完整性和密封剂渗透。

虽然EDTA仍然是黄金标准，但对其毒性和环境持久性的担忧促使人们寻找生物友好型替代品。我们评价了EDDS对根管封闭剂显微硬度、涂抹层和牙本质渗透的影响。使用了215颗圆形单根牙齿。样品用溶液处理3 min。分析了维氏显微硬度。最终灌洗：GroupET: 17%-EDTA；-edds分组:15%;-naocl GroupET / N: 17% edta + 2.5%;分组/ N: 15% -naocl -edds + 2.5%;GroupC:蒸馏水。评估涂片层。用环氧树脂和生物陶瓷封闭剂封闭根管。用共聚焦显微镜分析牙本质穿透性。采用单因素方差分析、学生t检验、Fisher-Freeman-Halton-exact检验和Wilcoxon符号秩检验。EDTA和EDDS对显微硬度、涂片层和牙本质渗透的影响相似（p < 0.05）。生物陶瓷-封闭剂能提高牙本质的穿透性，NaOCl能增强牙本质的穿透性(p

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.