The Therapeutic Potential of Phaseolus vulgaris in Alzheimer's Disease: Insights From Experimental Rodent Model.

Abstract

Alzheimer's disease (AD) is a devastating neurological ailment affecting millions of people worldwide. For this neurological disease, there are numerous pharmacological and supportive treatments available. Several organic products are currently being investigated for AD. In a recent study, a variety of methods were used to conduct research and evaluate this advantageous effect, including passive avoidance tests, histopathology, biogenic amine assessment, and GC-MS analysis. For this study, three groups were made of albino rats of both genders. Group I was the negative control group (administered standard diet), Group II was treated with 500 mg/kg beans, and Group III was given 1000 mg/kg. All three groups were induced Alzheimer's by giving 2.5 mg/kg diazepam prior to the start of the treatment. The results showed that a significantly higher dosage level of 1000 mg/kg was most effective at preventing dementia in AD-induced rats as compared to the lower dose evaluated. Passive avoidance tests, GC-MS analysis, which revealed acetylcholine activity and other beneficial compounds like squalene, isoglutamine, and pyrrolizine, as well as histopathological analysis, all supported the effectiveness of this nutritional option. The findings unmistakably demonstrated that 1000 mg/kg red beans are very helpful in reducing dementia in AD-induced rats.