Immune implications and therapeutic opportunities of tumor glycosylation

IF 28 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2026-07-15 DOI:10.1038/s43018-026-01200-8

Remi Hatinguais, Stan Verjans, Joana Gomes, Sandra J. van Vliet

引用次数: 0

Abstract

Aberrant glycosylation is a nearly universal hallmark of cancer cells. Tumor-associated glycans can reshape cancer cell biology and act as crucial suppressors of anti-tumor immunity. By engaging immune inhibitory receptors or by modifying the function of immune checkpoints, glycans dampen natural immune responses and immunotherapy efficacy. Therefore, glycans serve both as direct targets for anticancer interventions and as adjuvants aimed at potentiating immunotherapy success. In this Review, we provide an overview of tumor glycosylation and its impact on cancer immune surveillance. Finally, we discuss recent therapeutic developments that highlight the potential of glycans as precision cancer medicines. In this Review, van Vliet and colleagues provide an overview of aberrant glycosylation as a hallmark of cancer cells, focusing on its impact for cancer immunity and therapeutic opportunities.

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肿瘤糖基化的免疫意义和治疗机会。

异常糖基化几乎是癌细胞的普遍特征。肿瘤相关聚糖可以重塑癌细胞生物学，并作为抗肿瘤免疫的重要抑制因子。通过参与免疫抑制受体或通过修改免疫检查点的功能，聚糖抑制自然免疫反应和免疫治疗的效果。因此，聚糖既可以作为抗癌干预的直接靶点，也可以作为增强免疫治疗成功的佐剂。在这篇综述中，我们概述了肿瘤糖基化及其对癌症免疫监测的影响。最后，我们讨论了最近的治疗发展，突出了聚糖作为精确癌症药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.