A polyadenylation enzyme rewires metabolism to fuel AML

IF 28 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2026-07-15 DOI:10.1038/s43018-026-01180-9

Animesh Kar, Daniel Herranz

引用次数: 0

Abstract

mRNA polyadenylation is a tightly controlled process, but its role in cancer remains poorly understood. A study now shows that the RNA-modifying enzyme poly(A) polymerase α (PAPOLA) is crucial for acute myeloid leukemia generation and progression via an axis that can be effectively targeted therapeutically, offering new hope for patients.

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一种聚腺苷化酶重新连接代谢以促进急性髓性白血病。

mRNA聚腺苷化是一个严格控制的过程，但其在癌症中的作用仍然知之甚少。一项研究表明，rna修饰酶聚(A)聚合酶α (PAPOLA)在急性髓系白血病的产生和进展中起着至关重要的作用，它可以有效地靶向治疗，为患者带来新的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.