A targetable micropeptide reprograms macrophages to suppress T cell anti-tumor immunity

IF 28 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2026-07-15 DOI:10.1038/s43018-026-01196-1

引用次数: 0

Abstract

We identify UEIS, a micropeptide expressed in tumor-associated macrophages (TAMs), as a suppressor of anti-tumor immunity. In both human cells and mouse models, UEIS dampened cGAS–STING–type I interferon signaling in TAMs by sequestering TBK1 within biomolecular condensates in a negative feedback loop. Targeted disruption of UEIS condensation restored anti-tumor responses and improved the efficacy of immune checkpoint blockade.

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一种可靶向的微肽重编程巨噬细胞以抑制T细胞抗肿瘤免疫。

我们确定了UEIS，一种在肿瘤相关巨噬细胞（tam）中表达的微肽，作为抗肿瘤免疫的抑制因子。在人类细胞和小鼠模型中，UEIS通过在负反馈回路中将TBK1隔离在生物分子凝聚物中来抑制TAMs中的cgas - sting - I型干扰素信号。靶向破坏UEIS凝集恢复抗肿瘤反应，提高免疫检查点阻断的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.