Cuproptosis promotes antitumour immunity

IF 60.7 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2026-07-15 DOI:10.1038/s41568-026-00964-6

Daniela Senft

引用次数: 0

Abstract

In a recent study, Lei, Lu, Xu et al. identify cuproptosis as a form of immunogenic cell death that stimulates adaptive antitumour immunity. In turn, CD8⁺ T cell-derived IFNγ enhances tumour sensitivity to cuproptosis through STAT1–IRF1–FDX1 signalling, establishing a reciprocal immunometabolic circuit with important implications for cancer immunotherapy.

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cuprotosis促进抗肿瘤免疫。

在最近的一项研究中，Lei、Lu、Xu等人发现cuprotosis是一种免疫原性细胞死亡形式，可刺激适应性抗肿瘤免疫。反过来，CD8 + T细胞衍生的IFNγ通过STAT1-IRF1-FDX1信号传导增强了肿瘤对铜坏死的敏感性，建立了一个互惠的免疫代谢回路，对癌症免疫治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.