Comparative Study of Clinical Characteristics According to Pain Distribution in Lingual Burning Mouth Syndrome

IF 3.8 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation Pub Date : 2026-10-10 Epub Date: 2026-07-15 DOI:10.1111/joor.70269

Yoohyun Sim, Na-Yeon Ha, Seok-Jae Ko, Jae-Woo Park, Jinsung Kim

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引用次数: 0

Abstract

Background

The pathophysiology of burning mouth syndrome (BMS) remains unclear.

Objectives

To compare the clinical characteristics of patients with lingual BMS according to pain distribution.

Methods

The medical records of patients with lingual BMS who visited the oral clinic of Kyung Hee University Korean Medicine Hospital between January 2023 and December 2024 were retrospectively reviewed. Patients were classified according to tongue pain distribution as follows: laterality (unilateral vs. bilateral), extent (localised vs. generalised) and central tongue involvement (non-central vs. central involvement). Group differences and associations among clinical characteristics, including pain intensity (visual analog scale [VAS]), quality of life, salivary flow and taste disturbance, were assessed.

Results

In total, 256 patients were included. Patients with bilateral pain showed significantly higher pain intensity than those with unilateral pain. Patients with generalised pain reported significantly higher pain intensity than those with localised pain. Patients with central involvement showed significantly higher pain intensity than those with non-central involvement. Pain intensity was negatively associated with quality of life in most subgroups, except the unilateral subgroup. Taste disturbance was associated with clinically significant pain (VAS ≥ 4) in the unilateral and localised subgroups, whereas reduced salivary flow was associated with clinically significant pain in the central involvement subgroup.

Conclusions

Pain distribution may help identify clinical subtypes of lingual BMS and support individualised assessment. Herein, pain distribution was associated with differences in pain intensity, quality of life, taste disturbance and salivary flow, underscoring the heterogeneous and multifactorial pathophysiology of lingual BMS and the need for tailored management.

查看原文本刊更多论文

舌灼口综合征临床特征与疼痛分布的比较研究。

背景：灼口综合征（BMS）的病理生理机制尚不清楚。目的：比较不同疼痛分布的舌部BMS患者的临床特点。方法：回顾性分析2023年1月至2024年12月在庆熙大学韩国医院口腔门诊就诊的舌性BMS患者的病历。根据舌痛分布对患者进行分类：侧边性（单侧vs双侧）、程度（局部vs全身性）和舌央受累（非中枢性vs中枢性）。评估临床特征的组间差异及相关性，包括疼痛强度（视觉模拟量表[VAS]）、生活质量、唾液流和味觉障碍。结果：共纳入患者256例。双侧疼痛患者疼痛强度明显高于单侧疼痛患者。全身性疼痛患者报告的疼痛强度明显高于局部疼痛患者。中枢性受累患者的疼痛强度明显高于非中枢性受累患者。在大多数亚组中，除了单侧亚组外，疼痛强度与生活质量呈负相关。在单侧和局部亚组中，味觉障碍与临床显著性疼痛相关（VAS≥4），而在中枢受累亚组中，唾液流量减少与临床显著性疼痛相关。结论：疼痛分布可能有助于识别舌部BMS的临床亚型，并支持个体化评估。在此，疼痛分布与疼痛强度、生活质量、味觉障碍和唾液流动的差异有关，强调了舌部BMS的异质性和多因素病理生理，需要量身定制的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.