{"title":"Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus <i>Penicillium herquei</i>.","authors":"Yi-Yang Xiong, Lin-Lin Li, Jing Huang, Meng-Yi Deng, Xian-Li Zhou","doi":"10.1080/10286020.2026.2701131","DOIUrl":null,"url":null,"abstract":"<p><p>Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (<b>1</b>, <b>2</b>), four aromatic derivatives (<b>3</b>-<b>6</b>), two cyclopeptides (<b>7</b>, <b>8</b>), two acyclic sesquiterpenes (<b>9</b>-<b>10</b>), four fatty acid esters (<b>11</b>-<b>14</b>) and two fatty acids (<b>15</b>-<b>16</b>), were separated from the endophytic fungus <i>Penicillium herquei</i>. Their structures were established by analysis of spectroscopic data, HRESIMS spectra, NMR data and comparison with data in relevant literature. It is the first time that all of these compounds were isolated from <i>P. herquei</i>. The <i>in vitro</i> cytotoxicity of all isolated was evaluated against four tumor cell lines (HCT116, A549, HeLa, and Hepg2 cells) by the MTT assay, and compounds <b>1</b>, <b>2</b>, <b>4</b>, <b>7</b> and <b>8</b> exhibited cytotoxicity with IC<sub>50</sub> values ranging from 9.7 ± 0.8 to 37.4 ± 2.5 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2026.2701131","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (1, 2), four aromatic derivatives (3-6), two cyclopeptides (7, 8), two acyclic sesquiterpenes (9-10), four fatty acid esters (11-14) and two fatty acids (15-16), were separated from the endophytic fungus Penicillium herquei. Their structures were established by analysis of spectroscopic data, HRESIMS spectra, NMR data and comparison with data in relevant literature. It is the first time that all of these compounds were isolated from P. herquei. The in vitro cytotoxicity of all isolated was evaluated against four tumor cell lines (HCT116, A549, HeLa, and Hepg2 cells) by the MTT assay, and compounds 1, 2, 4, 7 and 8 exhibited cytotoxicity with IC50 values ranging from 9.7 ± 0.8 to 37.4 ± 2.5 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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