Blood Metabolites Mediate the Effects of Gut Microbiota on Diabetic Nephropathy: A Mendelian Randomization Study.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI:10.1155/ije/6642332

Weiwei Zhang, Yun Zhang, Huijuan Yuan

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引用次数: 0

Abstract

Background: The gut microbiota (GM) might be related to diabetic nephropathy (DN). The role of blood metabolites, immune cells, and plasma lipidomes in mediating the impact of GM on DN remains unexplored.

Methods: 412 GM, 1400 blood metabolites, 731 immune cells, 179 plasma lipidomes, and DN were identified through genome-wide association study (GWAS) datasets. We employed Mendelian randomization (MR) to investigate the relationship among GM, blood metabolomes, immune cells, plasma lipidomes, and DN. Furthermore, we conducted mediation analyses to ascertain if the blood metabolomes, immune cells, and plasma lipidomes function as mediators.

Results: Our research identified suggestive causal linkages among 15 GM, 27 immune cells, 27 plasma lipidomes, and 55 blood metabolites associated with DN. Mediation analysis showed that advanced glycation end products (AGEs) pyrraline may mediate the causal relationship between s_Bacteroides_eggerthii and DN, with a mediation percentage of 39.96% (p = 0.015). Furthermore, immune cells and plasma lipidomes do not appear to play a mediating role.

Conclusion: Gut microbiota, blood metabolomes, immune cells, and plasma lipidomes were causally linked to DN. The blood metabolite pyrraline may act as a potential mediator by which s_Bacteroides_eggerthii influences the risk of developing DN.

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血液代谢物介导肠道微生物群对糖尿病肾病的影响：一项孟德尔随机研究

背景：肠道微生物群（GM）可能与糖尿病肾病（DN）有关。血液代谢物、免疫细胞和血浆脂质体在介导转基因对DN的影响中的作用仍未被探索。方法：通过全基因组关联研究（GWAS）数据集，鉴定出412个GM、1400个血液代谢物、731个免疫细胞、179个血浆脂质组和DN。我们采用孟德尔随机化（MR）来研究GM、血液代谢组、免疫细胞、血浆脂质组和DN之间的关系。此外，我们还进行了中介分析，以确定血液代谢组、免疫细胞和血浆脂质组是否起中介作用。结果：我们的研究确定了与DN相关的15个GM、27个免疫细胞、27个血浆脂质体和55个血液代谢物之间的暗示因果关系。中介分析表明，晚期糖基化终产物pyrraline可能介导s_Bacteroides_eggerthii与DN之间的因果关系，中介率为39.96% （p = 0.015）。此外，免疫细胞和血浆脂质体似乎不发挥中介作用。结论：肠道菌群、血液代谢组、免疫细胞和血浆脂质组与DN有因果关系。血液代谢物吡咯碱可能作为一种潜在的介质，通过这种介质s_Bacteroides_eggerthii影响发生DN的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

5.20

自引率

0.00%

发文量

147

审稿时长

1 months

期刊介绍： International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.