Selective chemical reprogramming of tumor-associated macrophages

IF 15.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2026-07-15 DOI:10.1038/s41589-026-02285-z

引用次数: 0

Abstract

Tumor immune cell targeting chimeras (TICTACs) exploit CD206-mediated internalization of immune checkpoint receptors by CD206high tumor-associated macrophages to induce their selective degradation. This approach has potential to overcome a major barrier to solid tumor immunotherapy while mitigating the off-tumor toxicity that arises from systemic immune activation.

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肿瘤相关巨噬细胞的选择性化学重编程。

肿瘤免疫细胞靶向嵌合体（TICTACs）利用cd206介导的免疫检查点受体内化，通过高cd206的肿瘤相关巨噬细胞诱导其选择性降解。这种方法有可能克服实体瘤免疫治疗的主要障碍，同时减轻由全身免疫激活引起的肿瘤外毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.