Biological Markers of Burnout Severity: A Systematic Review.

IF 2.9 2区心理学 Q2 PSYCHIATRY

Stress and Health Pub Date : 2026-08-01 DOI:10.1002/smi.70205

Maddalena Balia, Franck Zenasni, Maryne Lepoittevin, Alaedine Benani, Renzo Bianchi, Adrien Julian, Sylvain Bodard, Marie Bringer

{"title":"Biological Markers of Burnout Severity: A Systematic Review.","authors":"Maddalena Balia, Franck Zenasni, Maryne Lepoittevin, Alaedine Benani, Renzo Bianchi, Adrien Julian, Sylvain Bodard, Marie Bringer","doi":"10.1002/smi.70205","DOIUrl":null,"url":null,"abstract":"<p><p>Burnout syndrome (BOS) represents an enduring challenge for preventive medicine. While biomarkers of chronic stress have been explored within the allostatic load framework, BOS lacks a consistent physiological signature, hindering early and comprehensive identification of individuals at risk. This systematic review synthesises current evidence on BOS-related biomarkers, aiming to identify potential physiological correlates. We conducted a comprehensive search of PubMed and EMBASE, yielding 111 studies evaluating 36 biomarkers in adult populations. Our analysis revealed inconsistent associations across most physiological systems, including the hypothalamic-pituitary-adrenal axis (e.g., cortisol, DHEA), the immune system, and cardiovascular parameters. While some biomarkers such as HbA1c and blood glucose showed relatively more consistent associations with BOS, the overall findings remain largely inconclusive. Overall, the current biological evidence is insufficient to identify a BOS biosignature that could support routine clinical diagnosis. Future research should prioritise a more unified and comprehensive definition of BOS and investigate physiological patterns within more standardized research frameworks to advance objective identification and prevention strategies.</p>","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":"42 4","pages":"e70205"},"PeriodicalIF":2.9000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370058/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stress and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/smi.70205","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Burnout syndrome (BOS) represents an enduring challenge for preventive medicine. While biomarkers of chronic stress have been explored within the allostatic load framework, BOS lacks a consistent physiological signature, hindering early and comprehensive identification of individuals at risk. This systematic review synthesises current evidence on BOS-related biomarkers, aiming to identify potential physiological correlates. We conducted a comprehensive search of PubMed and EMBASE, yielding 111 studies evaluating 36 biomarkers in adult populations. Our analysis revealed inconsistent associations across most physiological systems, including the hypothalamic-pituitary-adrenal axis (e.g., cortisol, DHEA), the immune system, and cardiovascular parameters. While some biomarkers such as HbA1c and blood glucose showed relatively more consistent associations with BOS, the overall findings remain largely inconclusive. Overall, the current biological evidence is insufficient to identify a BOS biosignature that could support routine clinical diagnosis. Future research should prioritise a more unified and comprehensive definition of BOS and investigate physiological patterns within more standardized research frameworks to advance objective identification and prevention strategies.

查看原文本刊更多论文

倦怠严重程度的生物学标记：一项系统综述。

职业倦怠综合征（BOS）是预防医学面临的一个长期挑战。虽然在适应负荷框架内已经探索了慢性应激的生物标志物，但BOS缺乏一致的生理特征，阻碍了对高危个体的早期和全面识别。本系统综述综合了目前关于bos相关生物标志物的证据，旨在确定潜在的生理相关性。我们对PubMed和EMBASE进行了全面的检索，获得了111项研究，评估了成人人群中的36种生物标志物。我们的分析揭示了大多数生理系统之间不一致的关联，包括下丘脑-垂体-肾上腺轴（例如，皮质醇，脱氢表雄酮），免疫系统和心血管参数。虽然一些生物标志物，如HbA1c和血糖显示出与BOS相对更一致的关联，但总体发现在很大程度上仍不确定。总的来说，目前的生物学证据不足以确定能够支持常规临床诊断的BOS生物特征。未来的研究应优先考虑更统一和全面的BOS定义，并在更标准化的研究框架内调查生理模式，以推进客观识别和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Stress and Health 医学-精神病学

CiteScore

6.40

自引率

4.90%

发文量

审稿时长

>12 weeks

期刊介绍： Stress is a normal component of life and a number of mechanisms exist to cope with its effects. The stresses that challenge man"s existence in our modern society may result in failure of these coping mechanisms, with resultant stress-induced illness. The aim of the journal therefore is to provide a forum for discussion of all aspects of stress which affect the individual in both health and disease. The Journal explores the subject from as many aspects as possible, so that when stress becomes a consideration, health information can be presented as to the best ways by which to minimise its effects.