Evaluation of Insulin-Like Growth Factor-1 and Insulin Resistance in Patients With Central Serous Chorioretinopathy.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-08-01 Epub Date: 2026-07-14 DOI:10.3928/23258160-20260528-01

Naciye Tora, Günhal Şatırtav, Filiz Alkan Baylan, Hürkan Kerimoğlu, Mehmet Okka, Ali Tezcan

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引用次数: 0

Abstract

Background and objective: This study aimed to investigate serum levels of insulin-like growth factor-1 (IGF-1) and its association with parameters related to insulin resistance, in patients diagnosed with central serous chorioretinopathy (CSCR).

Patients and methods: In this cross-sectional comparative study, patients were classified as simple (n = 30) or complex (n = 25) CSCR based on multimodal imaging findings. Following a comprehensive ophthalmologic examination, fasting venous blood samples were collected for the biochemical analysis of glucose, insulin, IGF-1, C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Subsequently, body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) values were calculated for each participant.

Results: Mean serum IGF-1 levels were significantly higher in simple and complex CSCR groups compared with controls (P < .05). No significant differences were observed among the groups in glucose, HbA1c, CRP, BMI, or HOMA-IR (P > .05).

Conclusion: Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.

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中枢性浆液性脉络膜视网膜病变患者胰岛素样生长因子-1和胰岛素抵抗的评价。

背景与目的：本研究旨在探讨中枢性浆液性脉络膜视网膜病变（CSCR）患者血清胰岛素样生长因子-1 （IGF-1）水平及其与胰岛素抵抗相关参数的关系。患者和方法：在这项横断面比较研究中，根据多模态成像结果将患者分为单纯性（n = 30）和复合性（n = 25） CSCR。在全面眼科检查后，采集空腹静脉血样本进行葡萄糖、胰岛素、IGF-1、c反应蛋白（CRP）和糖化血红蛋白（HbA1c）的生化分析。随后，计算每个参与者的体重指数（BMI）和胰岛素抵抗稳态模型评估（HOMA-IR）值。结果：单纯CSCR组和复杂CSCR组血清IGF-1水平均显著高于对照组（P < 0.05）。各组间血糖、HbA1c、CRP、BMI或HOMA-IR无显著差异（P < 0.05）。结论：CSCR患者IGF-1水平升高表明该生长因子可能通过脉络膜血管通透性和视网膜内皮活性参与疾病发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.