Recent progress in nanoparticulate lipid-based co-delivery systems containing gene-based cargoes for the treatment of oncological and non-oncological diseases.
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引用次数: 0
Abstract
Lipid-based nanoparticulate systems provide a versatile and multifaceted platform that directly addresses critical drug delivery challenges. By encapsulating a diverse spectrum of therapeutic agents, these systems significantly enhance biocompatibility, improve bioavailability, and ensure superior stability, thereby maximizing therapeutic potential. These systems can act as non-viral vectors for successful delivery of gene-based molecules to required sites and provide the desired therapeutic effects. Conversely, the implementation of a co-delivery strategy for both oncological and non-oncological conditions holds significant promise for substantially improving clinical outcomes, and one of the main platforms for achieving synergistic effects is employing lipid-based systems. This article aims to review the recent progress in co-delivery approaches by employing lipid-based delivery systems containing gene-based cargoes.
期刊介绍：
Pharmaceutical Development & Technology publishes research on the design, development, manufacture, and evaluation of conventional and novel drug delivery systems, emphasizing practical solutions and applications to theoretical and research-based problems. The journal aims to publish significant, innovative and original research to advance the frontiers of pharmaceutical development and technology.
Through original articles, reviews (where prior discussion with the EIC is encouraged), short reports, book reviews and technical notes, Pharmaceutical Development & Technology covers aspects such as:
-Preformulation and pharmaceutical formulation studies
-Pharmaceutical materials selection and characterization
-Pharmaceutical process development, engineering, scale-up and industrialisation, and process validation
-QbD in the form a risk assessment and DoE driven approaches
-Design of dosage forms and drug delivery systems
-Emerging pharmaceutical formulation and drug delivery technologies with a focus on personalised therapies
-Drug delivery systems research and quality improvement
-Pharmaceutical regulatory affairs
This journal will not consider for publication manuscripts focusing purely on clinical evaluations, botanicals, or animal models.
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