Hydrogel-Mediated Delivery of Drug Nanocarriers in the Oedematous Postoperative Brain.

IF 4.1 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2026-08-01 Epub Date: 2026-07-14 DOI:10.1007/s11095-026-04155-8

Noel Benton, Wenbo Zhan

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引用次数: 0

Abstract

PURPOSE AND OBJECTIVES: Hydrogel-nanocarrier systems have emerged as a clinically implementable strategy to reduce glioblastoma recurrence following surgery. Despite demonstrated feasibility, the influence of intrinsic tissue and nanocarrier properties on delivery outcomes remains insufficiently understood. This study aims to quantify their individual effects on delivery performance.

Methods: A mathematical model is applied to simulate hydrogel-mediated nanocarrier delivery to the oedematous postoperative brain. Simulations are conducted in a realistic 3-D brain geometry rebuilt from medical imaging data. Nine factors are investigated, including drug release rate, nanocarrier diffusivity, blood drainage rate, partitioning at the cell membrane and within cells, drug loading dose, oedema severity, blood pressure, and tissue permeability.

Results: The modelling reveals distinct responses of delivery outcomes to each factor. Optimal ranges are identified that maximise drug availability and/or improve distribution volume and uniformity. The results suggest that drug delivery is controlled predominantly by drug release and elimination rather than transport.

Conclusions: These findings enhance understanding of the coupled interactions between drug transport and brain tissue in the post-operative environment and provide a quantitative reference for the optimisation of hydrogel-nanocarrier delivery systems to improve inhibition of glioblastoma recurrence.

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水凝胶介导的药物纳米载体在术后脑水肿中的递送。

目的和目的：水凝胶-纳米载体系统已成为临床可实施的策略，以减少手术后胶质母细胞瘤复发。尽管证明了可行性，但内在组织和纳米载体性质对递送结果的影响仍未得到充分了解。本研究旨在量化他们对交付绩效的个人影响。方法：应用数学模型模拟水凝胶介导的纳米载体在术后水肿脑内的传递。模拟在一个真实的三维大脑几何重建从医学成像数据。研究了药物释放率、纳米载体扩散率、血液引流率、细胞膜和细胞内分配、载药剂量、水肿严重程度、血压和组织通透性等9个因素。结果：模型揭示了每个因素对交付结果的不同反应。确定最佳范围，最大限度地提高药物可获得性和/或改善分配量和均匀性。结果表明，药物传递主要受药物释放和消除而不是运输控制。结论：这些发现增强了对术后环境中药物转运与脑组织耦合相互作用的认识，并为优化水凝胶-纳米载体递送系统以提高对胶质母细胞瘤复发的抑制作用提供了定量参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.