Impact of autoimmune thyroiditis on IVF outcomes in patients with polycystic ovary syndrome and chronic endometritis.

IF 5.3 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2026-07-14 DOI:10.1186/s13048-026-02189-5

Dingran Wang, Zheng Wang, Hongbin Chi, Rong Li, Shuo Yang

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引用次数: 0

Abstract

Question: To investigate the impact of autoimmune thyroiditis (AIT) on IVF/ICSI outcomes in patients with polycystic ovary syndrome (PCOS) and chronic endometritis (CE).

Design: This retrospective cohort study analyzed 444 oocyte retrieval cycles from patients with PCOS and CE who underwent IVF/ICSI treatment at Peking University Third Hospital between January 2018 and December 2020. Eligible patients were infertile women who had undergone hysteroscopic surgery with endometrial pathology available. CE was defined as CD138 positivity on endometrial biopsy, and AIT was defined as positivity for TPOAb or TGAb. Of 444 cycles, 96 were AIT-positive and 348 were AIT-negative. Baseline characteristics, controlled ovarian stimulation (COS) parameters, embryological outcomes, fresh-cycle pregnancy outcomes, and cumulative live birth rate (CLBR) were compared between groups. Multivariable logistic regression was performed to identify independent predictors of CLBR.

Results: The prevalence of AIT was not significantly different between patients with and without endometritis (20.63% vs. 19.17%, P = 0.265). Among patients with PCOS and CE, baseline characteristics were comparable between the AIT and non-AIT groups, except for a slightly longer infertility duration in the AIT group. The fresh-cycle live birth rate was lower in the AIT group than in the non-AIT group (5.71% [2/35] vs. 23.66% [31/131], P = 0.021). However, CLBR did not differ significantly between groups (34.38% [33/96] vs. 41.38% [144/348], P = 0.222). In multivariate analysis, the number of high-quality embryos was independently associated with CLBR (OR = 1.138, 95% CI 1.053-1.231, P = 0.001).

Conclusion: AIT was not associated with the prevalence of CE or with CLBR in patients with PCOS and CE. A lower fresh-cycle live birth rate was observed in the AIT group, but this finding should be confirmed in larger studies. Increasing the number of high-quality embryos may improve CLBR in patients with PCOS and CE.

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自身免疫性甲状腺炎对多囊卵巢综合征和慢性子宫内膜炎患者体外受精结果的影响

目的：探讨自身免疫性甲状腺炎（AIT）对多囊卵巢综合征（PCOS）和慢性子宫内膜炎（CE）患者IVF/ICSI结果的影响。设计：本回顾性队列研究分析了2018年1月至2020年12月在北京大学第三医院接受IVF/ICSI治疗的PCOS和CE患者的444个卵母细胞回收周期。符合条件的患者是接受子宫内膜病理检查的不孕症妇女。CE定义为子宫内膜活检CD138阳性，AIT定义为TPOAb或TGAb阳性。在444个周期中，96个ait阳性，348个ait阴性。比较两组患者的基线特征、可控卵巢刺激（COS）参数、胚胎学结局、新鲜周期妊娠结局和累计活产率（CLBR）。采用多变量logistic回归来确定CLBR的独立预测因子。结果：子宫内膜炎患者与非子宫内膜炎患者AIT患病率差异无统计学意义（20.63% vs. 19.17%, P = 0.265）。在PCOS和CE患者中，AIT组和非AIT组的基线特征是相似的，除了AIT组的不孕持续时间稍长。AIT组新鲜周期活产率低于非AIT组（5.71% [2/35]vs. 23.66% [31/131], P = 0.021）。但两组间CLBR差异无统计学意义（34.38%[33/96]对41.38% [144/348],P = 0.222）。在多变量分析中，高质量胚胎的数量与CLBR独立相关（OR = 1.138, 95% CI 1.053-1.231, P = 0.001）。结论：AIT与PCOS和CE患者的CE患病率或CLBR无关。在AIT组观察到较低的新鲜周期活产率，但这一发现应在更大规模的研究中得到证实。增加高质量胚胎的数量可能会改善PCOS和CE患者的CLBR。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.