Vitamin A and retinoids in the treatment of olfactory dysfunction: a systematic review.

IF 1.1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2026-07-15 DOI:10.1017/S0022215126105507

Kiran Joshi, Dilen Parmar, Heide Mills

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引用次数: 0

Abstract

Objective: To assess the efficacy and safety of vitamin A and retinoid analogues for adult olfactory dysfunction.

Methods: A review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines searched PubMed, Embase, Web of Science and the Cochrane Library from inception to September 2025 for clinical studies evaluating vitamin A or retinoids. Eligible designs included randomised trials, controlled trials, prospective cohorts and large case series.

Results: Eight studies including 589 participants were identified. Findings were inconsistent: observational studies and pilot trials suggested possible benefit, particularly in post-infectious disease and with olfactory training, whereas two randomised trials found no significant added benefit. Safety reporting was limited.

Conclusions: Current evidence does not support routine vitamin A treatment for olfactory dysfunction. Any benefit is uncertain and may be phenotype-, route- or dose-specific; adequately powered trials using standardised endpoints and adverse-event reporting are required.

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维生素A和类维生素A治疗嗅觉功能障碍：系统综述。

目的：评价维生素A和类维甲酸类似物治疗成人嗅觉功能障碍的疗效和安全性。方法：根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，检索PubMed， Embase， Web of Science和Cochrane图书馆，从成立到2025年9月，评估维生素A或类维生素A的临床研究。符合条件的设计包括随机试验、对照试验、前瞻性队列和大型病例系列。结果：共纳入8项研究，包括589名参与者。结果不一致：观察性研究和试点试验表明可能有益，特别是在感染后疾病和嗅觉训练中，而两项随机试验没有发现显著的额外益处。安全报告是有限的。结论：目前的证据不支持常规的维生素A治疗嗅觉功能障碍。任何益处都是不确定的，可能是表现型、途径或剂量特异性的；需要使用标准化终点和不良事件报告的充分有力的试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.