Breviscapine alleviates liver fibrosis by inhibiting epithelial-mesenchymal transition via TGF-beta1/Smad3 pathway.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-07-14 DOI:10.1080/10286020.2026.2697867

Xiu-Hong Zhong, Yao Li, Yu-Kun Song, Yan-Mei Sun, Dong-Fang Zhang, Hai-Chao Ge, Ying-Li He

引用次数: 0

Abstract

Liver fibrosis may develop into cirrhosis and liver cancer, lacking effective approved treatments. Breviscapine extracted from Erigeron breviscapus possesses low toxicity and favorable pharmacokinetics, yet its anti-fibrotic mechanisms remain unclear. This study verified its protective effects on cell and rat fibrosis models. It suppresses HSC activation and ECM accumulation by inhibiting TGF-β1/Smad3 pathway, reversing EMT. Breviscapine is a promising candidate for hepatic fibrosis therapy.

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灯盏花素通过tgf - β 1/Smad3途径抑制上皮-间质转化，减轻肝纤维化。

肝纤维化可能发展为肝硬化和肝癌，缺乏有效的批准治疗。从灯盏花中提取的灯盏花素具有低毒性和良好的药动学特性，但其抗纤维化机制尚不清楚。本研究证实了其对细胞和大鼠纤维化模型的保护作用。通过抑制TGF-β1/Smad3通路抑制HSC活化和ECM积累，逆转EMT。灯盏花素是一种很有前途的肝纤维化治疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.