Three new steroidal alkaloids from the whole plants of Sarcococca ruscifolia.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-07-15 DOI:10.1080/10286020.2026.2697865

Yong-Jin Ye, Xiao-Hui Sun, Gang Ke, Pu-Zhao Zhang, Ya-Mei Zhang

引用次数: 0

Abstract

ABETRACTThree previously undescribed steroidal alkaloids, 20α-N,N-dimethylamino-2β-hydroxy-3α-senecioylamino-5α-pregnane (1), 20α-N,N-dimethylamino-2β,4α-dihydroxy-3α-senecioylamino-5α-pregnane (2) and 20α-N,N-dimethylamino-2β,15α-dihydroxy-3α-senecioylamino-5α-pregn-16-ene (3), were isolated from the whole plants of Sarcococca ruscifolia. Their structures were determined through the analysis of physiochemical properties and spectroscopic data. Compound 1 showed a certain inhibitory effect on human glioma U251 cells with an IC₅₀ value of 13.51 μM.

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三种新甾体生物碱的全株提取。

ababtract20 α- n， n-二甲氨基-2β-羟基-3α- senecioylamin5 α-孕烷(1),20α-N， n-二甲氨基-2β，4α-二羟基-3α- senecioylamin5 - α-孕烷(2)和20α-N， n-二甲氨基-2β，15α-二羟基-3α- senecioylamin5 - α-孕烷-16-烯(3)，这3种甾体生物碱是先前未被描述过的。通过理化性质和光谱数据分析确定了它们的结构。化合物1对人胶质瘤U251细胞有一定的抑制作用，IC50值为13.51 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.