Jan Luca Budde, Mehdi D Davari, Ahmed Hassanin, Mikail Karacam, Andreas Kirschning, Henry Struwe, Daghan Taser
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引用次数: 0
Abstract
Covering: up to 2026A traditional view regarding enzymes assigns them a markedly low substrate promiscuity. This is based, among other factors, on concepts concerning the evolution of metabolism, which, according to the "patchwork model", assumes that the first enzymes converted a variety of substrates more or less effectively into quite different products and that enzymes then differentiated through evolution and became more substrate selective. Starting from linear oligoprenyl diphosphate precursors, terpene synthases produce oligocyclic terpenes via complex carbocation cascades. It was found that these sometimes exhibit unusual substrate acceptance. Using the example of the fungal sesquiterpene synthase BcBOT2, it is shown that the "terpenome" can be expanded in an unprecedented way, whereby completely new terpene backbones can be generated that nature is usually unable to access, as of today.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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