Food-Based Dietary Inflammatory Index in Relation to Breast Cancer.

IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Preventive Medicine Pub Date : 2026-05-22 eCollection Date: 2026-01-01 DOI:10.4103/ijpvm.ijpvm_262_24

Niloofar Eshaghian, Yaser Sharif, Omid Sadeghi, Sanaz Benisi-Kohansal, Leila Azadbakht, Gholamreza Askari, Ahmad Esmaillzadeh

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引用次数: 0

Abstract

Background: There is no study on the association between food-based dietary inflammatory index (FDII) and odds of breast cancer. This study was conducted to investigate the association between FDII and odds of breast cancer in Iranian women.

Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed new cases of breast cancer and 700 controls which were matched with cases in terms of age and socioeconomic status. FDII score was calculated based on participants' dietary intakes.

Results: A significant positive association was found between FDII and odds of breast cancer (odds ratio [OR]: 1.38, 95% confidence interval [CI]: 1.01-1.88); such that after taking potential confounders into account, women in the highest tertile of FDII score were 1.52 time more likely to have breast cancer compared with those in the lowest tertile (OR: 1.52, 95% CI: 1.05-2.18). Such a significant positive association was also observed among postmenopausal women, either before (OR: 1.53, 95% CI: 1.09-2.14) or after (OR: 1.54, 95% CI: 1.05-2.27) controlling for covariates. The same association was also observed in normal-weight women, and it remained significant even after controlling for potential confounders (OR: 1.58, 95% CI: 1.04-2.41).

Conclusions: We found a significant positive association between FDII and the odds of breast cancer in women, particularly postmenopausal ones.

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基于食物的饮食炎症指数与乳腺癌的关系。

背景：目前还没有关于以食物为基础的饮食炎症指数（FDII）与乳腺癌发病率之间关系的研究。本研究旨在调查伊朗女性FDII与乳腺癌发病率之间的关系。方法：在这项以人群为基础的病例对照研究中，我们招募了350例病理确诊的新发乳腺癌病例和700例年龄和社会经济地位匹配的对照组。FDII评分是根据参与者的饮食摄入量计算的。结果：FDII与乳腺癌发病率之间存在显著正相关（优势比[OR]: 1.38, 95%可信区间[CI]: 1.01-1.88）；因此，在考虑了潜在的混杂因素后，FDII得分最高的女性患乳腺癌的可能性是得分最低的女性的1.52倍（OR: 1.52, 95% CI: 1.05-2.18）。在控制协变量之前（OR: 1.53, 95% CI: 1.09-2.14）或之后（OR: 1.54, 95% CI: 1.05-2.27），绝经后妇女中也观察到这种显著的正相关。在正常体重的女性中也观察到同样的关联，即使在控制了潜在的混杂因素后，它仍然显著（OR: 1.58, 95% CI: 1.04-2.41）。结论：我们发现FDII与女性患乳腺癌的几率显著正相关，尤其是绝经后的女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

4.80%

发文量

107

期刊介绍： International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.